Fear extinction learning modulates large-scale brain connectivity.
Fear extinction learning modulates large-scale brain connectivity.
复制标题
恐惧灭绝学习调节大型大脑连接性。
DOI：
10.1016/j.neuroimage.2021.118261
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发表时间：
2021-09
期刊：
影响因子：
5.7
通讯作者：
Milad MR
中科院分区：
文献类型：
--
作者：
Wen Z;Chen ZS;Milad MR
探索条件性恐惧消退的神经回路对于促进我们对恐惧和焦虑相关疾病的理解至关重要。该领域的重点是研究内侧前额叶皮层、岛叶皮层、海马和杏仁核的各个区域在条件恐惧及其消退中的作用。这种“恐惧网络”对有意识地意识到恐惧的贡献最近受到了质疑。因此，有必要检查可能有助于有意识的恐惧和焦虑感的更高/多个皮层系统。在这里，我们研究了整个大脑的功能连接模式，以检查多个网络对恐惧消退学习的获得及其检索的贡献。我们对来自137名健康参与者的数据进行了逐个试验的分析，这些参与者在功能性磁共振成像（fMRI）扫描仪中接受了为期两天的恐惧条件反射和消退范式。我们发现，从早期到晚期，灭绝学习只在条件提示下才增加了大脑各区域的功能连接，其中许多是默认模式、额顶叶和腹侧注意力网络的一部分。在灭绝学习过程中增加的连通性预测了24小时后测试的灭绝记忆的大小。总之，这些发现提供了支持最近研究的证据，这些研究涉及分布式大脑区域在人类大脑中学习，巩固和表达恐惧消退记忆。
Exploring the neural circuits of the extinction of conditioned fear is critical to advance our understanding of fear-and anxiety-related disorders. The field has focused on examining the role of various regions of the medial prefrontal cortex, insular cortex, hippocampus, and amygdala in conditioned fear and its extinction. The contribution of this ‘fear network’ to the conscious awareness of fear has recently been questioned. And as such, there is a need to examine higher/multiple cortical systems that might contribute to the conscious feeling of fear and anxiety. Herein, we studied functional connectivity patterns across the entire brain to examine the contribution of multiple networks to the acquisition of fear extinction learning and its retrieval. We conducted trial-by-trial analyses on data from 137 healthy participants who underwent a two-day fear conditioning and extinction paradigm in a functional magnetic resonance imaging (fMRI) scanner. We found that functional connectivity across a broad range of brain regions, many of which are part of the default mode, frontoparietal, and ventral attention networks, increased from early to late extinction learning only to a conditioned cue. The increased connectivity during extinction learning predicted the magnitude of extinction memory tested 24 h later. Together, these findings provide evidence supporting recent studies implicating distributed brain regions in learning, consolidation and expression of fear extinction memory in the human brain.
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DOI：
10.1038/s41583-018-0039-7
发表时间：
2018-09
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Fenster RJ;Lebois LAM;Ressler KJ;Suh J
通讯作者：
Suh J
影响因子：
5.8
作者：
Kelly, Clare;Castellanos, F. Xavier
通讯作者：
Castellanos, F. Xavier
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
2.7
作者：
Apergis-Schoute AM;Schiller D;LeDoux JE;Phelps EA
通讯作者：
Phelps EA
影响因子：
5.7
作者：
Cisler JM;Bush K;Steele JS
通讯作者：
Steele JS