Extinction resistant changes in the human auditory association cortex following threat learning.
Extinction resistant changes in the human auditory association cortex following threat learning.
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DOI：
10.1016/j.nlm.2014.01.016
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发表时间：
2014-09
影响因子：
2.7
通讯作者：
Phelps EA
中科院分区：
文献类型：
--
作者：
Apergis-Schoute AM;Schiller D;LeDoux JE;Phelps EA
对人类的研究已经强调了杏仁核对皮层区域的短暂调节的重要性，以增强对情绪刺激的处理。然而，非人类动物数据表明，依赖于杏仁核的威胁（恐惧）学习也会导致皮质敏感性的长期持续变化，即使在恐惧反应消失后也会持续存在。人类对这种条件作用的长期痕迹的神经机制尚未被探索。我们使用功能磁共振成像（fMRI）评估了在威胁获取、消退学习和消退检索过程中的皮肤电导反应（SCR）。我们提供了威胁消失后人类大脑皮层持续可塑性的证据，并表明听觉关联皮层中习得威胁刺激的血氧水平依赖（BOLD）信号增强抵抗消失。这些发现指出了一个平行的途径，即皮层对潜在危险刺激的处理可以持续很长时间，即使即时威胁和相关的杏仁核调节已经消退。
Research in humans has highlighted the importance of the amygdala for transient modulation of cortical areas for enhanced processing of emotional stimuli. However, non-human animal data has shown that amygdala dependent threat (fear) learning can also lead to long lasting changes in cortical sensitivity, persisting even after extinction of fear responses. The neural mechanisms of long-lasting traces of such conditioning in humans have not yet been explored. We used functional magnetic resonance imaging (fMRI) and assessed skin conductance responses (SCR) during threat acquisition, extinction learning and extinction retrieval. We provide evidence of lasting cortical plasticity in the human brain following threat extinction and show that enhanced blood oxygen level-dependent (BOLD) signal to the learned threat stimulus in the auditory association cortex is resistant to extinction. These findings point to a parallel avenue by which cortical processing of potentially dangerous stimuli can be long lasting, even when immediate threat and the associated amygdala modulation have subsided.
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影响因子：
16.2
作者：
Rotshtein, P;Malach, R;Hendler, T
通讯作者：
Hendler, T
影响因子：
16.2
作者：
LaBar, KS;Gatenby, JC;Phelps, EA
通讯作者：
Phelps, EA
影响因子：
16.2
作者：
Quirk, GJ;Armony, JL;LeDoux, JE
通讯作者：
LeDoux, JE
DOI：
10.1037/0097-7403.1.1.88
发表时间：
1975-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
RESCORLA, RA;HETH, CD
通讯作者：
HETH, CD
影响因子：
64.8
作者：
Milad, MR;Quirk, GJ
通讯作者：
Quirk, GJ