First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium.
First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium.
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海洋蓝细菌中丙糖蛋白和42-羟基淀一蛋白的第一个证据。
DOI：
10.3390/md9040543
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发表时间：
2011
期刊：
影响因子：
5.4
通讯作者：
Laurent D
中科院分区：
文献类型：
--
作者：
Kerbrat AS;Amzil Z;Pawlowiez R;Golubic S;Sibat M;Darius HT;Chinain M;Laurent D
海洋中上层重氮营养类蓝藻Trichodesum(Oscillatoriales)广泛分布于热带和亚热带，在新喀里多尼亚水域尤为常见。毛霉菌的大量繁殖被怀疑是雪卡鱼食物链中的潜在毒素来源，此前有报道称，它含有几种类型的麻痹毒素。木霉(Trichodesum spp.)用小鼠生物法和神经母细胞瘤法对其进行了分析，并用液相色谱-串联质谱法对其毒性化合物进行了表征。在这里，我们报告了在新喀里多尼亚泻湖采集的毛霉的野外样品中首次鉴定出孢霉毒素及其衍生物--42-羟基孢霉毒素。文中还讨论了水华毛霉在藻毒素发展中的可能作用，这种人类在摄食浮游生物食性鱼类后的中毒，传统上与水华水华有关。
Marine pelagic diazotrophic cyanobacteria of the genus Trichodesmium (Oscillatoriales) are widespread throughout the tropics and subtropics, and are particularly common in the waters of New Caledonia. Blooms of Trichodesmium are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain several types of paralyzing toxins. The toxicity of water-soluble extracts of Trichodesmium spp. were analyzed by mouse bioassay and Neuroblastoma assay and their toxic compounds characterized using liquid chromatography coupled with tandem mass spectrometry techniques. Here, we report the first identification of palytoxin and one of its derivatives, 42-hydroxy-palytoxin, in field samples of Trichodesmium collected in the New Caledonian lagoon. The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed.
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影响因子：
2.8
作者：
Aligizaki, Katerina;Katikou, Panagiota;Diogene, Jorge
通讯作者：
Diogene, Jorge
影响因子：
2.1
作者：
Abed, Raeid M. M.;Palinska, Katarzyna A.;Golubic, Stjepko
通讯作者：
Golubic, Stjepko
影响因子：
2.8
作者：
ENDEAN, R;MONKS, SA;LLEWELLYN, LE
通讯作者：
LLEWELLYN, LE
影响因子：
2.9
作者：
JANSON, S;SIDDIQUI, PJA;BERGMAN, B
通讯作者：
BERGMAN, B
影响因子：
2.8
作者：
Dickey, Robert W.;Plakas, Steven M.
通讯作者：
Plakas, Steven M.