Quantitative techniques in 18FDG PET scanning in oncology.

Quantitative techniques in 18FDG PET scanning in oncology.
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DOI:
10.1038/sj.bjc.6604330
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发表时间:
2008-05-20
影响因子:
8.8
通讯作者:
Cook GJ
Cook GJ
中科院分区:
医学1区
文献类型:
--
作者:
Castell F;Cook GJ

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18氟-2-脱氧葡萄糖(18 FDG)正电子发射断层扫描(PET)在肿瘤学中的临床应用正在逐步建立。虽然简单的静态扫描技术用于大多数常规临床检查,但在临床试验中越来越多地使用PET来监测18FDG和反映不同药效学终点的新型示踪剂的治疗反应,通常需要对放射性药物动力学进行更复杂和定量的分析。PET分析技术的范围很广,从简单的视觉分析和半定量方法到动力学分析的全动态研究。这些方法进行了讨论,特别侧重于可用的方法,可以在临床试验中使用。
The clinical applications of 18F-fluoro-2-deoxyglucose (18FDG) positron emission tomography (PET) in oncology are becoming established. While simple static scanning techniques are used for the majority of routine clinical examinations, increasing use of PET in clinical trials to monitor treatment response with 18FDG and novel tracers reflecting different pharmacodynamic end points, often necessitates a more complex and quantitative analysis of radiopharmaceutical kinetics. A wide range of PET analysis techniques exist, ranging from simple visual analysis and semiquantitative methods to full dynamic studies with kinetic analysis. These methods are discussed, focusing particularly on the available methodologies that can be utilised in clinical trials.
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