Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus, electrophysiology, metabolomics, and gut microbiota.
Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus, electrophysiology, metabolomics, and gut microbiota.
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DOI：
10.1016/j.isci.2021.103113
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发表时间：
2021-10-22
期刊：
影响因子：
5.8
通讯作者：
Burnet PWJ
中科院分区：
文献类型：
--
作者：
Spitzer SO;Tkacz A;Savignac HM;Cooper M;Giallourou N;Mann EO;Bannerman DM;Swann JR;Anthony DC;Poole PS;Burnet PWJ
我们之前已经表明，向新生大鼠施用益生元（Bimuno半乳糖-低聚糖，B-GOS®）增加了海马NMDAR蛋白。本研究调查了出生后B-GOS®补充剂对年轻，青少年和成年大鼠的海马依赖性行为的影响，并应用电生理学，代谢组学和宏基因组学分析来探索潜在的潜在机制。对哺乳期但非断奶后的大鼠施用B-GOS®可减少焦虑行为，直至成年。新生儿益生元摄入还减少了海马NMDAR电流的快速衰减成分，改变了大脑，肠道和肝脏代谢组的年龄特异性轨迹，并减少了粪便肠球菌和Dorea细菌的丰度。我们的数据首次表明，在特定的出生后时期给予大鼠益生元对行为和海马生理学具有长期影响。该研究还表明，早期益生元摄入可能会通过减少与压力相关的肠道细菌而不是增加有益微生物的增殖来影响宿主的大脑功能。在生命早期补充B-GOS®益生元具有抗焦虑作用，抗焦虑作用持续到成年期产后B-GOS®补充剂改变海马NMDAR和突触事件的动力学B-GOS®改变大脑、消化系统和肝脏的生化老化分子生理学;神经科学;微生物学
We have shown previously that prebiotic (Bimuno galacto-oligosacharides, B-GOS®) administration to neonatal rats increased hippocampal NMDAR proteins. The present study has investigated the effects of postnatal B-GOS® supplementation on hippocampus-dependent behavior in young, adolescent, and adult rats and applied electrophysiological, metabolomic and metagenomic analyses to explore potential underlying mechanisms. The administration of B-GOS® to suckling, but not post-weaned, rats reduced anxious behavior until adulthood. Neonatal prebiotic intake also reduced the fast decay component of hippocampal NMDAR currents, altered age-specific trajectories of the brain, intestinal, and liver metabolomes, and reduced abundance of fecal Enterococcus and Dorea bacteria. Our data are the first to show that prebiotic administration to rats during a specific postnatal period has long-term effects on behavior and hippocampal physiology. The study also suggests that early-life prebiotic intake may affect host brain function through the reduction of stress-related gut bacteria rather than increasing the proliferation of beneficial microbes. B-GOS® prebiotic supplementation early in life has anxiolytic effects Anxiolytic effects last until adulthood Postnatal B-GOS® supplements changes kinetics of hippocampal NMDARs and synaptic events B-GOS® alters biochemical aging of the brain, digestive system, and the liver Molecular physiology; Neuroscience; Microbiology
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影响因子：
30.3
作者：
Cahenzli J;Köller Y;Wyss M;Geuking MB;McCoy KD
通讯作者：
McCoy KD
影响因子：
10.6
作者：
Carlson AL;Xia K;Azcarate-Peril MA;Goldman BD;Ahn M;Styner MA;Thompson AL;Geng X;Gilmore JH;Knickmeyer RC
通讯作者：
Knickmeyer RC
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
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抗生素诱导的大肠微生物群调节改变了仔猪下丘脑的芳香氨基酸谱和神经递质表达
影响因子：
4.7
作者：
Gao, Kan;Pi, Yu;Zhu, Wei-Yun
通讯作者：
Zhu, Wei-Yun
影响因子：
5.3
作者：
Cathala, L;Misra, C;Cull-Candy, S
通讯作者：
Cull-Candy, S