Clinical Translation of Tissue Engineered Trachea Grafts.
Clinical Translation of Tissue Engineered Trachea Grafts.
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DOI：
10.1177/0003489416656646
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Breuer CK
中科院分区：
文献类型：
--
作者：
Chiang T;Pepper V;Best C;Onwuka E;Breuer CK
本文就组织工程气管重建的最新进展作一综述。对截至2015年10月（含）的当前文献进行结构化PubMed检索。对组织工程化气管移植物（TETG）的翻译进行了综述。生物相容性支持物与自体细胞的整合已导致呼吸道上皮、软骨和血管化的成功再生以及移植物的通畅性，尽管最佳的构建物组成尚未确定。与补片气管成形术相比，节段性TETG结构更常见于狭窄和延迟上皮形成。人类TETG受体的近期历史代表了再生医学原理研究的革命性证据。TETG的应用仍然局限于同情使用的基础上，然而，定义软骨形成，上皮形成和体内再生的细化机制将推进TETG从实验室到床边的翻译。
To provide a state-of-the-art review discussing recent achievements in tissue engineered tracheal reconstruction. A structured PubMed search of the current literature up to and including October 2015. Representative articles that discuss the translation of tissue engineered tracheal grafts (TETG) were reviewed. The integration of a biologically compatible support with autologous cells has resulted in successful regeneration of respiratory epithelium, cartilage, and vascularization with graft patency, although the optimal construct composition has yet to be defined. Segmental TETG constructs are more commonly complicated by stenosis and delayed epithelialization when compared to patch tracheoplasty. The recent history of human TETG recipients represents revolutionary proof of principle studies in regenerative medicine. Application of TETG remains limited to a compassionate use basis; however, defining the mechanisms of cartilage formation, epithelialization, and refinement of in vivo regeneration will advance the translation of TETG from the bench to the bedside.
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影响因子：
4.1
作者：
Berg, Malin;Ejnell, Hasse;Sumitran-Holgersson, Suchitra
通讯作者：
Sumitran-Holgersson, Suchitra
DOI：
10.1016/j.jtcvs.2009.10.002
发表时间：
2010-02-01
影响因子：
6
作者：
Go, Tetsuhiko;Jungebluth, Philipp;Macchiarini, Paolo
通讯作者：
Macchiarini, Paolo
影响因子：
14
作者：
Badylak, Stephen F.
通讯作者：
Badylak, Stephen F.
影响因子：
1.7
作者：
Fishman, Jonathan M.;Lowdell, Mark;Birchall, Martin A.
通讯作者：
Birchall, Martin A.
DOI：
10.1001/archotol.130.10.1191
发表时间：
2004-10-01
影响因子：
--
作者：
Grimmer, JF;Gunnlaugsson, CB;Weatherly, RA
通讯作者：
Weatherly, RA