Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea.
Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea.
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抗赖氨酰氧化酶与真空装置相结合，通过重塑白膜来诱导阴茎延长
DOI：
10.4103/aja.aja_120_19
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发表时间：
2020-09
影响因子：
2.9
通讯作者：
Yuan JH
中科院分区：
文献类型：
--
作者：
Li T;Fu FD;Wu CJ;Qin F;Wang R;Yuan JH
本研究旨在探讨抗赖氨酰氧化酶（anti-LOX）联合真空装置（VD）是否以及如何促进阴茎延长，并评估其对勃起功能的影响。本研究在四组成年大鼠中进行：对照组、抗LOX组、VD组（负压值为-300 mmHg）和抗LOX + VD组。阴茎长度用改良的VD法测量，并在暴露长度数据上进行验证。记录海绵体内压（ICP）和最大ICP/平均动脉压（MAP）比值以评估勃起功能。对于阴茎海绵体，LOX活性和吡啶啉，锁链素，羟脯氨酸和弹性蛋白的浓度进行了分析，透射电子显微镜和哈特的弹性蛋白染色进行监测显微结构的变化。与对照组相比，抗LOX和VD组的阴茎长度分别延长了10.8%（3.75 mm）和8.2%（2.48 mm），而抗LOX + VD组的阴茎长度最长（40.58 ± 0.40 mm），比对照组（34.58 ± 0.54 mm）长17.4%。洗脱1周后，未观察到阴茎回缩。同时，暴露的阴茎长度数据证实，抗LOX + VD组的阴茎也显著更长。抗LOX抗体通过抑制LOX活性降低吡啶啉水平，导致阴茎图尼卡白蛋白重构。然而，它对羟脯氨酸，锁链素和弹性蛋白水平没有影响。此外，抗LOX对勃起功能没有影响，这是由ICP和ICP/MAP比值确定的。这些结果表明，抗LOX通过减少吡啶啉延长阴茎，从而诱导图尼卡白蛋白重塑。当与VD结合时，这种延长效果更加明显。所有手术均对勃起功能无影响。
This study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control, anti-LOX, VD (negative pressure value of −300 mmHg), and anti-LOX + VD. Penile length was measured by a modified VD method and verified on exposed length data. Intracavernous pressure (ICP) and maximum ICP/mean arterial pressure (MAP) ratio were recorded to assess erectile function. For corpus cavernosum, LOX activity and concentrations of pyridinoline, desmosine, hydroxyproline, and elastin were analyzed; transmission electron microscope and Hart's elastin staining were performed to monitor microstructural changes. Anti-LOX and VD significantly lengthened the penis by 10.8% (3.75 mm) and 8.2% (2.48 mm) compared with the control group, respectively, while anti-LOX + VD achieved the longest penile size (40.58 ± 0.40 mm) which was 17.4% longer than the control group (34.58 ± 0.54 mm). After 1-week washout, no penile retraction was observed. Meanwhile, exposed penile length data confirmed that the penis in the anti-LOX + VD group was also significantly longer. Anti-LOX inhibited LOX activity to reduce pyridinoline level, which led the penile tunica albuginea remodeling. However, it had no effect on hydroxyproline, desmosine, and elastin levels. Moreover, anti-LOX had no impact on erectile function, which was determined by ICP and ICP/MAP ratio. These results suggest that anti-LOX elongates the penis by reducing pyridinoline, which induces tunica albuginea remodeling. This lengthening effect was more obvious when combined with a VD. All procedures had no impact on erectile function.
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