Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat.
Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat.
复制标题
心肌梗死时心肌细胞减少及其对大鼠缺血性心脏的治疗作用
DOI：
10.1111/j.1582-4934.2012.01655.x
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发表时间：
2013-01
影响因子：
5.3
通讯作者：
Cai D
中科院分区：
文献类型：
--
作者：
Zhao B;Chen S;Liu J;Yuan Z;Qi X;Qin J;Zheng X;Shen X;Yu Y;Qnin TJ;Chan JY;Cai D
最近，在心肌中发现了心肌端细胞。然而，心肌端细胞的功能作用和心肌梗死期间心肌端细胞群体的可能变化尚不清楚。在这项研究中，最近发现的心肌端细胞在心肌梗死（MI）的作用进行了调查。心肌终体细胞呈纵向分布，分布在心肌的交叉网络内，心肌梗死时受损。在实验性冠状动脉闭塞用于诱导MI后约4天至4周，梗死区的心脏端细胞不可检测。尽管缺血心脏的非缺血区域中的心脏端细胞经历了细胞死亡，但在实验性冠状动脉闭塞后约2周细胞密度增加。然后细胞密度维持在与左前降支冠状动脉（LAD）结扎后1-4天观察到的相似水平，但2周后仍低于正常水平。我们还发现，在心脏的梗死区和边缘区同时移植心脏端细胞可缩小梗死面积，改善心肌功能。这些数据表明，心脏端细胞，其分泌的因子和微泡，和微环境可能是结构和功能上的重要维护心肌的生理完整性。心肌梗死后梗死区端细胞网络的重建可能有利于梗死心肌的功能再生。
Recently, cardiac telocytes were found in the myocardium. However, the functional role of cardiac telocytes and possible changes in the cardiac telocyte population during myocardial infarction in the myocardium are not known. In this study, the role of the recently identified cardiac telocytes in myocardial infarction (MI) was investigated. Cardiac telocytes were distributed longitudinally and within the cross network of the myocardium, which was impaired during MI. Cardiac telocytes in the infarction zone were undetectable from approximately 4 days to 4 weeks after an experimental coronary occlusion was used to induce MI. Although cardiac telocytes in the non‐ischaemic area of the ischaemic heart experienced cell death, the cell density increased approximately 2 weeks after experimental coronary occlusion. The cell density was then maintained at a level similar to that observed 1–4 days after left anterior descending coronary artery (LAD)‐ligation, but was still lower than normal after 2 weeks. We also found that simultaneous transplantation of cardiac telocytes in the infarcted and border zones of the heart decreased the infarction size and improved myocardial function. These data indicate that cardiac telocytes, their secreted factors and microvesicles, and the microenvironment may be structurally and functionally important for maintenance of the physiological integrity of the myocardium. Rebuilding the cardiac telocyte network in the infarcted zone following MI may be beneficial for functional regeneration of the infarcted myocardium.
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影响因子：
5.3
作者：
Cantarero Carmona I;Luesma Bartolomé MJ;Junquera Escribano C
通讯作者：
Junquera Escribano C
影响因子：
5.3
作者：
Kostin S
通讯作者：
Kostin S
影响因子：
5.3
作者：
Manole CG;Cismaşiu V;Gherghiceanu M;Popescu LM
通讯作者：
Popescu LM
产前和产后生活期间端细胞和心肌细胞之间的关系。
影响因子：
5.3
作者：
Faussone-Pellegrini MS;Bani D
通讯作者：
Bani D
心脏成纤维细胞通过Beta1整合素信号传导调节心肌增殖。
影响因子：
11.8
作者：
Leda, Masaki;Tsuchihashi, Takatoshi;Ivey, Kathryn N.;Ross, Robert S.;Hong, Ting-Ting;Shaw, Robin M.;Srivastava, Deepak
通讯作者：
Srivastava, Deepak