Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas.
Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas.
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DOI：
10.1021/acs.nanolett.6b00599
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发表时间：
2016-05-11
期刊：
影响因子：
10.8
通讯作者：
Meade, Thomas J.
中科院分区：
文献类型：
--
作者：
Holbrook, Robert J.;Rammohan, Nikhil;Rotz, Matthew W.;MacRenaris, Keith W.;Preslar, Adam T.;Meade, Thomas J.
胰腺腺癌的5年生存率约为3%，中位生存率为6个月，是所有医学中预后最糟糕的疾病之一。这种不良预后主要是由于延迟诊断，患者在出现晚期疾病之前没有症状。因此，早期发现胰腺腺癌的技术是迫切需要的。胰腺组织成像是出了名的困难，新的成像技术的发展将影响我们对器官生理学和病理学的理解，并应用于疾病诊断、分期和体内治疗的纵向反应。磁共振成像（MRI）为这些类型的调查提供了许多优势；然而，由于这种组织类型的固有对比度较低，它无法描绘胰腺。为了克服这一限制，我们制备了一种新的Gd（III）造影剂，该造影剂可在胰腺中积聚，并通过MR成像提供显着的对比度增强。我们描述了一种新的二硫烷- gd （III）配合物的合成和表征，以及一种直接和可扩展的结合金纳米颗粒的方法。我们提供的数据表明，由于高Gd（III）载荷，纳米共轭物在低磁场强度和高磁场强度下都表现出非常高的每粒子r1弛度值。我们提供胰腺组织标记的证据，包括MR图像，死后生物分布分析和胰腺组织颗粒定位评估。观察到明显的对比度增强，可以清晰地识别胰腺，对比噪声比超过35:1。
Pancreatic adenocarcinoma has a 5 year survival of approximately 3% and median survival of 6 months and is among the most dismal of prognoses in all of medicine. This poor prognosis is largely due to delayed diagnosis where patients remain asymptomatic until advanced disease is present. Therefore, techniques to allow early detection of pancreatic adenocarcinoma are desperately needed. Imaging of pancreatic tissue is notoriously difficult, and the development of new imaging techniques would impact our understanding of organ physiology and pathology with applications in disease diagnosis, staging, and longitudinal response to therapy in vivo. Magnetic resonance imaging (MRI) provides numerous advantages for these types of investigations; however, it is unable to delineate the pancreas due to low inherent contrast within this tissue type. To overcome this limitation, we have prepared a new Gd(III) contrast agent that accumulates in the pancreas and provides significant contrast enhancement by MR imaging. We describe the synthesis and characterization of a new dithiolane-Gd(III) complex and a straightforward and scalable approach for conjugation to a gold nanoparticle. We present data that show the nanoconjugates exhibit very high per particle values of r1 relaxivity at both low and high magnetic field strengths due to the high Gd(III) payload. We provide evidence of pancreatic tissue labeling that includes MR images, post-mortem biodistribution analysis, and pancreatic tissue evaluation of particle localization. Significant contrast enhancement was observed allowing clear identification of the pancreas with contrast-to-noise ratios exceeding 35:1.
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影响因子：
15
作者：
Harrison VS;Carney CE;MacRenaris KW;Waters EA;Meade TJ
通讯作者：
Meade TJ
影响因子：
6.4
作者：
Grimm, J;Potthast, A;Moore, A
通讯作者：
Moore, A
影响因子：
2.2
作者：
Botsikas, Diomidis;Terraz, Sylvain;Montet, Xavier
通讯作者：
Montet, Xavier
DOI：
10.1102/1470-7330.2006.0035
发表时间：
2006-12-20
期刊：
Cancer imaging : the official publication of the International Cancer Imaging Society
影响因子：
--
作者：
Schima, Wolfgang
通讯作者：
Schima, Wolfgang
DOI：
10.1084/jem.20011794
发表时间：
2002-12-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bellingan GJ;Xu P;Cooksley H;Cauldwell H;Shock A;Bottoms S;Haslett C;Mutsaers SE;Laurent GJ
通讯作者：
Laurent GJ