Potential generation of nano-sized mist by passing a solution through dielectric barrier discharge
Potential generation of nano-sized mist by passing a solution through dielectric barrier discharge
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DOI：
10.1038/s41598-022-14670-4
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发表时间：
2022-06-22
影响因子：
4.6
通讯作者：
Yoshino, Daisuke
中科院分区：
文献类型：
--
作者：
Watanabe, Ryosuke;Tanaka, Shiori;Miyaji, Godai;Yoshino, Daisuke
血浆医学是一种利用常压等离子体的治疗技术，作为医学领域的一种创新工具而备受关注。大多数等离子体生物医学工具使用直接作用，如热、光刺激和反应性化学物质，对病变。利用等离子体间接作用（即产生电场）的纳米关节技术有可能被应用于促进透皮吸收，即药物通过皮肤的屏障功能并渗透到内部组织中。在这里，我们展示了一种通过介质阻挡放电使溶液直接产生纳米级雾的方法。这种方法使我们能够在纳米尺寸范围内生产水基和油基溶液的雾。等离子体诱导的物理和化学特性（包括电导率、粘度和化学物质）的变化影响了雾的产生。我们期望开发的纳米级雾产生方法为透皮吸收系统的应用提供一种技术，包括与药物和化妆品相关的应用。
Plasma medicine, a therapeutic technology that uses atmospheric-pressure plasma, is attracting much attention as an innovative tool for the medical field. Most of the plasma biomedical tools use direct effects, such as heat, optical stimulation, and reactive chemical species, on the lesion. Nanoparticulation techniques using indirect action by plasma, i.e., generation of electric fields, have the potential to be applied to promote transdermal absorption, where drugs pass through the barrier function of skin and penetrate into internal tissues. Here, we show a method to directly generate the nano-sized mist by passing a solution through the dielectric barrier discharge. This method enables us to produce the mist potentially in the nanometer size range for both water-based and oil-based solutions. Ease of mist generation was influenced by the plasma-induced changes in physical and chemical characteristics, including electrical conductivity, viscosity, and chemical species. We anticipate the developed method for nano-sized mist generation to provide a technique in the applications of the transdermal absorption system, including those related to pharmaceuticals and cosmetics.
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DOI：
10.1016/b978-0-12-801238-3.11028-1
发表时间：
2019-01-01
期刊：
ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1
影响因子：
--
作者：
Wang, Min;Zhao, Qilong
通讯作者：
Zhao, Qilong
影响因子：
5.7
作者：
Yu YQ;Yang X;Wu XF;Fan YB
通讯作者：
Fan YB
影响因子：
1.4
作者：
Machala, Z.;Janda, M.;Morvova, M.
通讯作者：
Morvova, M.
影响因子：
2.7
作者：
Saied, Mona A.;Mansour, Sarnia H.;Nour, Kamal N. Abdell
通讯作者：
Nour, Kamal N. Abdell
影响因子：
5.5
作者：
Zeb, Alam;Arif, Sadia Tabassam;Kim, Jin-Ki
通讯作者：
Kim, Jin-Ki