Near-infrared light triggered activation of pro-drug combination cancer therapy and induction of immunogenic cell death.
Near-infrared light triggered activation of pro-drug combination cancer therapy and induction of immunogenic cell death.
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近红外光触发前药组合癌症疗法的活化和免疫原性细胞死亡的诱导。
DOI：
10.1016/j.ijpharm.2021.120972
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发表时间：
2021-09-25
影响因子：
5.8
通讯作者：
Li F
中科院分区：
文献类型：
--
作者：
Kang X;Cai Y;Wang Q;Wang C;Chen W;Yang W;Suryawanshi A;Zhou G;Chen P;Li F
二硫铜配合物[Cu(DDC)2]纳米颗粒是一种很有前景的抗癌药物，但也存在毒副作用。为了提高肿瘤特异性，增强抗癌效果，我们开发了一种新型的[硫化铜纳米颗粒(cu NP) +双硫脲前药（DQ）胶束+近红外（NIR）激光]（CDL）联合治疗方法。DQ是一种活性氧（ROS）应答的前药，可以在肿瘤部位选择性激活ROS，释放DDC并原位形成Cu(DDC)2。CuS NP + NIR激光治疗可有效提高肿瘤内ROS水平，有效激活DQ前药。CDL治疗通过多种机制杀死癌细胞，包括ROS扩增级联和Cu(DDC)2化疗。近红外光触发的肿瘤特异性“无毒到有毒”转变可以显著提高抗癌作用的特异性，降低全身毒性。此外，CDL治疗可以有效诱导免疫原性细胞死亡（ICD），并具有激发抗肿瘤免疫的潜力。
Disulfiram copper complex [Cu(DDC)2] nanoparticles have been explored as promising anticancer agents but with concerns of toxic side effects. To improve tumor specificity and enhance anticancer efficacy, we developed a novel [copper sulfide nanoparticle (CuS NP) + disulfiram prodrug (DQ) micelle + near-infrared (NIR) laser] (CDL) combination therapy. DQ, a reactive oxygen species (ROS)-responsive prodrug, can be selectively activated at the tumor site with elevated ROS to release DDC and form Cu(DDC)2 in situ. The CuS NP + NIR laser treatment can effectively increase the intra-tumor ROS levels and efficiently activate the DQ prodrug. The CDL therapy kills cancer cells through multiple mechanisms, including ROS amplification cascade and Cu(DDC)2 chemotherapy. NIR light-triggered tumor-specific “nontoxic-to-toxic” transition can significantly improve the specificity of anticancer effects and reduce systemic toxicity. Also, CDL therapy can effectively induce immunogenic cell death (ICD) and has the potential of eliciting antitumor immunity.
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影响因子：
5.9
作者：
Chu, Zhongyun;Wang, Zhiming;Jia, Nengqin
通讯作者：
Jia, Nengqin
影响因子：
8
作者：
Li, Bin;Jiang, Zhongyin;Lao, Xingzhen
通讯作者：
Lao, Xingzhen
影响因子：
17.1
作者：
Ku, Geng;Zhou, Min;Song, Shaoli;Huang, Qian;Hazle, John;Li, Chun
通讯作者：
Li, Chun
基于 CuS@MSN 的治疗诊断纳米医学的体内肿瘤脉管系统靶向。
影响因子：
17.1
作者：
Chen, Feng;Hong, Hao;Goel, Shreya;Graves, Stephen A.;Orbay, Hakan;Ehlerding, Emily B.;Shi, Sixiang;Theuer, Charles P.;Nickles, Robert J.;Cai, Weibo
通讯作者：
Cai, Weibo
影响因子：
5.4
作者：
Li, Feng;Danquah, Michael;Mahato, Ram I.
通讯作者：
Mahato, Ram I.