The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information.
The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information.
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DOI：
10.1038/s41598-022-24173-x
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发表时间：
2022-11-16
影响因子：
4.6
通讯作者：
Norman, Andrew B.
中科院分区：
文献类型：
--
作者：
Tsibulsky, Vladimir L.;Norman, Andrew B.
药物递送的渐进比（PR）时间表用于确定动物的“激励”状态和药物的“增强功效”。这一被广泛接受的解释主要得到以下观察结果的支持：PR断点（BP）与自我给药药物的单位剂量成比例。应用可卡因自我给药的强迫区理论来确定它是否可以解释大鼠在PR时间表下的按压行为和可卡因注射的模式。该理论指出，可卡因在水平低于饱腹感阈值且高于启动/缓解阈值时诱导杠杆按压。训练大鼠在一定范围的可卡因单位剂量上以固定比率FR 1时间表自我施用可卡因。然后他们被切换到公关时间表。对于PR时间表下的自我给药，当计算的可卡因水平处于饱腹感区时，发生长时间注射后停顿。强迫区理论将血压简单地解释为大鼠在注射可卡因后，当可卡因水平保持在强迫区内时所能做出的最大反应次数。划定强制区的阈值非常稳定，独立于自我管理时间表。PR和固定比例方案传达相同的药代动力学/药效学信息，即，这两个时间表是不变的。
Progressive ratio (PR) schedules of drug delivery are used to determine the ‘motivational’ state of an animal and drug ‘reinforcing efficacy’. This widely held interpretation is supported mainly by the observation that the PR breakpoint (BP) is proportional to the unit dose of self-administered drug. The compulsion zone theory of cocaine self-administration was applied to determine whether it can explain the pattern of lever-pressing behavior and cocaine injections under the PR schedule in rats. This theory states that cocaine induces lever pressing when levels are below the satiety threshold and above the priming/remission threshold. Rats were trained to self-administer cocaine on a fixed ratio FR1 schedule over a range of cocaine unit doses. Then they were switched to a PR schedule. Typical for the self-administration under a PR schedule, long post-injection pauses occurred when calculated cocaine levels were in the satiety zone. The compulsion zone theory interprets BP simply as the maximal number of responses which rats can perform after an injection while cocaine levels remain within the compulsion zone. The thresholds delineating the compulsion zone were very stable and independent of the self-administration schedule. PR and fixed ratio schedules convey the same pharmacokinetic/pharmacodynamic information, i.e., these two schedules are invariant.
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影响因子：
8.2
作者：
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影响因子：
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作者：
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