Understanding Biofilms and Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated Infections.
Understanding Biofilms and Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated Infections.
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DOI：
10.1016/j.idc.2018.06.009
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发表时间：
2018-12
影响因子：
4.4
通讯作者：
Patel R
中科院分区：
文献类型：
--
作者：
Wi YM;Patel R
医疗器械相关感染的治疗具有挑战性，复发很常见。其主要原因是微生物粘附在医疗器械的表面，并进入生物膜状态，在该生物膜状态下，与它们的寄生虫对应物相比，它们显示出不同的生长速率、结构特征以及对抗菌剂和宿主免疫机制的保护。本文综述了微生物如何形成生物膜，以及生物膜对抗菌剂和宿主免疫系统的保护机制。还讨论了诊断生物膜相关感染的创新策略，以及治疗和预防医疗器械相关感染的新方法。
Treatment of medical device-related infections is challenging, and recurrence is common. The main reason for this is that microorganisms adhere to the surfaces of medical devices, and enter into a biofilm state in which they display distinct growth rates, structural features, and protection from antimicrobial agents and host immune mechanisms compared with their planktonic counterparts. This article reviews how microorganisms form biofilms and mechanisms of protection against antimicrobial agents and the host immune system provided by biofilms. Also discussed are innovative strategies for diagnosis of biofilm-associated infection, and novel approaches to treatment and prevention of medical device-associated infections.
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影响因子：
4.9
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