Is the rostro-caudal axis of the frontal lobe hierarchical?

Is the rostro-caudal axis of the frontal lobe hierarchical?
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DOI:
10.1038/nrn2667
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发表时间:
2009-09
影响因子:
34.7
通讯作者:
D'Esposito, Mark
D'Esposito, Mark
中科院分区:
医学1区
文献类型:
--
作者:
Badre, David;D'Esposito, Mark

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大脑的额叶是支持目标导向行为的大脑系统的一个组成部分。然而,它们的功能组织仍然存在争议。最近的研究报道了基于动作表征抽象性的额叶皮层活动的背尾差异。此外,一些人提出,这些差异反映了一种等级组织,即在实现抽象动作目标的运动行为过程中,前额叶区域影响后额叶区域的处理。然而,很少有人考虑额叶的解剖学和生理学是否支持这种方案。为了解决这一差距,本综述调查了解剖学、神经影像学、电生理学和发育方面的发现,并考虑了这样一个问题:额叶皮层的组织是分层的吗?
The frontal lobes in the brain are a component of the cerebral system that supports goal-directed behaviour. However, their functional organization remains controversial. Recent studies have reported rostro-caudal distinctions in frontal cortex activity based on the abstractness of action representations. In addition, some have proposed that these differences reflect a hierarchical organization, whereby anterior frontal regions influence processing by posterior frontal regions during the realization of abstract action goals as motor acts. However, few have considered whether the anatomy and physiology of the frontal lobes support such a scheme. To address this gap, this Review surveys anatomical, neuroimaging, electrophysiological and developmental findings, and considers the question: could the organization of the frontal cortex be hierarchical?
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