Malaria during pregnancy and transplacental transfer of Kaposi sarcoma-associated herpesvirus (KSHV) antibodies: a cohort study of Kenyan mother and child pairs.
Malaria during pregnancy and transplacental transfer of Kaposi sarcoma-associated herpesvirus (KSHV) antibodies: a cohort study of Kenyan mother and child pairs.
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DOI：
10.1186/s13027-020-00336-1
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发表时间：
2020-11-26
影响因子：
3.7
通讯作者：
Rochford R
中科院分区：
文献类型：
--
作者：
Sabourin KR;Ogolla S;Daud II;Jackson CL;Miley W;Labo N;Whitby D;Rochford R
到2岁时，撒哈拉以南非洲儿童的卡波西肉瘤相关疱疹病毒（KSHV）的血清患病率可高达50%，但影响早期KSHV感染的因素尚不清楚。妊娠期间的疟疾与几种病原体的抗体经胎盘转移受阻有关，但它是否影响KSHV抗体的经胎盘转移尚不清楚。我们的目的是确定子宫内疟疾暴露是否减少了KSHV抗体在胎盘中的转移。在肯尼亚基苏木进行的一项队列研究招募了第一次去产前诊所（ANC）就诊的孕妇，并跟踪她们直至分娩。我们纳入了70名kshv阳性、hiv阴性的母亲和她们的孩子。采用ELISA （K8.1, ORF73）和多重检测（K8.1, ORF73, K10.5, ORF38, ORF50）检测KSHV抗体水平。通过脐血与母血抗体比（CMR）测定抗体经胎盘转移情况。妊娠期疟疾定义为在任何ANC访问或分娩时检测到恶性疟原虫（Pf） DNA。在怀孕期间患有疟疾的妇女中，我们检查了分娩前最后一次疟疾感染的时间（< 27周vs.妊娠27周以上）和疟疾发病率（MIR）（发病率/100人周）。孕妇KSHV血清阳性率（ELISA检测K8.1或ORF73阳性）为88%。妊娠期疟疾、疟疾感染时间和MIR均与产妇分娩KSHV抗体血水平无关。产妇分娩和脐带血KSHV抗体水平高度相关，但这些相关性没有因怀孕期间的疟疾而不同。KSHV经胎盘抗体转移与妊娠期疟疾、疟疾感染时间和MIR无关。妊娠期间的疟疾似乎不影响KSHV抗体通过胎盘的转移。在线版本包含补充材料，可在10.1186/s13027-020-00336-1获得。
Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in sub-Saharan African children can range up to 50% by age 2 years but factors affecting early age of KSHV infection are not well understood. Malaria during pregnancy has been associated with hindered transplacental transfer of antibodies to several pathogens but whether it affects transplacental transfer of KSHV antibodies is unknown. We aimed to determine if in utero malaria exposure reduced the transfer of KSHV antibodies across the placenta. A cohort study in Kisumu, Kenya enrolled pregnant women at their first antenatal clinic (ANC) visit and followed them through delivery. We included 70 KSHV-positive, HIV-negative mothers and their children. KSHV antibody levels were measured by ELISA (K8.1, ORF73) and multiplex assay (K8.1, ORF73, K10.5, ORF38, ORF50). Transplacental transfer of antibodies was measured by the cord to maternal blood ratio (CMR) of KSHV antibodies. Malaria during pregnancy was defined as detection of Plasmodium falciparum (Pf) DNA at any ANC visit or delivery. Among women with malaria during pregnancy, we examined time of last malaria infection prior to delivery (< 27 vs. 27+ weeks gestation) and malaria incidence rate (MIR) (episodes/100 person-weeks). KSHV seroprevalence (positive for K8.1 or ORF73 by ELISA) among pregnant women was 88%. Neither malaria during pregnancy, malaria infection timing, nor MIR were associated with maternal delivery KSHV antibody blood levels. Maternal delivery and cord blood KSHV antibody levels were highly correlated but these correlations did not differ by malaria during pregnancy. KSHV transplacental antibody transfer was not associated with malaria during pregnancy, malaria infection timing, nor MIR. Malaria during pregnancy does not appear to affect transfer of KSHV antibodies across the placenta. The online version contains supplementary material available at 10.1186/s13027-020-00336-1.
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影响因子：
6.7
作者：
Labo N;Miley W;Marshall V;Gillette W;Esposito D;Bess M;Turano A;Uldrick T;Polizzotto MN;Wyvill KM;Bagni R;Yarchoan R;Whitby D
通讯作者：
Whitby D
影响因子：
2.3
作者：
Daud II;Ogolla S;Amolo AS;Namuyenga E;Simbiri K;Bukusi EA;Ng'ang'a ZW;Ploutz-Snyder R;Sumba PO;Dent A;Rochford R
通讯作者：
Rochford R
影响因子：
6.4
作者：
Nalwoga, Angela;Cose, Stephen;Newton, Robert
通讯作者：
Newton, Robert
影响因子：
6.4
作者：
BIGGAR, RJ;HENLE, W;HENLE, G
通讯作者：
HENLE, G
影响因子：
--
作者：
Ogolla, Sidney;Daud, Ibrahim I.;Rochford, Rosemary
通讯作者：
Rochford, Rosemary