Quantitative evaluation of light distribution in skin tissue for short-pulsed laser treatment using Monte Carlo simulation combined with nonlinear absorption model of melanin
Quantitative evaluation of light distribution in skin tissue for short-pulsed laser treatment using Monte Carlo simulation combined with nonlinear absorption model of melanin
复制标题
蒙特卡洛模拟结合黑色素非线性吸收模型定量评价短脉冲激光治疗皮肤组织光分布
DOI：
10.1117/12.2648157
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Awazu Kunio
中科院分区：
文献类型：
--
作者：
Shimojo Yu;Nishimura Takahiro;Awazu Kunio
皮秒和纳秒激光对色素性病变的治疗效果主要来自黑素体的光吸收。根据局部能量密度的线性吸收，评价了治疗效果的差异。然而，由于高功率密度，在皮肤组织中的短脉冲激光传播期间，黑色素体内的黑色素发生非线性吸收。我们先前的研究表明，一个非线性吸收模型的基础上的顺序双光子吸收和非辐射衰减被验证来描述黑色素的非线性吸收。在这项研究中，我们比较评估的光分布在皮肤组织与色素性病变照射短脉冲激光使用蒙特卡罗模型结合非线性吸收模型。在一个数值模型的人皮肤组织与表皮色素病变的光分布进行了计算，为一个单一的450 ps和10 ns的激光脉冲，在波长为532 nm，1 J/cm 2的能量密度，和3 mm的光斑大小。计算模拟表明，在皮肤组织中的穿透深度较短的皮秒激光。模拟结果表明，皮秒激光相比纳秒激光可以减少对周围组织的损伤。虽然这些结果需要通过实验验证，我们的模拟将提供一个定量评估的安全性和有效性的短脉冲激光治疗色素性病变。
The treatment effect of pigmented lesions with picosecond and nanosecond lasers is produced mainly from optical absorption by melanosomes. Differences in the treatment effect have been evaluated based on the linear absorption of local fluence. However, nonlinear absorption by melanin inside melanosomes occurs during short-pulsed laser propagation in skin tissue owing to the high-power density. Our previous study demonstrated that a nonlinear absorption model based on sequential two-photon absorption and nonradiative decays was validated to describe nonlinear absorption by melanin. In this study, we comparatively evaluate light distributions in skin tissue with pigmented lesions irradiated with short-pulsed lasers using a Monte Carlo model combined with the nonlinear absorption model. Light distributions in a numerical model of human skin tissue with epidermal pigmented lesions were calculated for a single shot of 450-ps and 10-ns laser pulses at a wavelength of 532 nm, a fluence of 1 J/cm2, and a spot size of 3 mm. The computational simulations show that the penetration depth in the skin tissue was shorter for the picosecond laser. The simulation results suggested that picosecond lasers can reduce damage to surrounding tissue compared to nanosecond lasers. Although these results need to be validated by experiments, our simulations will provide a quantitative evaluation of the safety and efficacy of short-pulsed laser treatment of pigmented lesions.
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影响因子：
1.6
作者：
Kim JY;Yang J;Huh G;Choi YJ;Kim WS
通讯作者：
Kim WS
吸收诱导热引发路径对激光诱导击穿的辐照度阈值的影响。
影响因子：
3.4
作者：
B. Varghese;V. Bonito;M. Jurna;J. Palero;M. Verhagen
通讯作者：
M. Verhagen
影响因子：
2.4
作者：
Ungaksornpairote, Chanida;Manuskiatti, Woraphong;Wanitphakdeedecha, Rungsima
通讯作者：
Wanitphakdeedecha, Rungsima
影响因子：
2.1
作者：
Vachiramon, Vasanop;Iamsumang, Wimolsiri;Triyangkulsri, Korn
通讯作者：
Triyangkulsri, Korn
影响因子：
2.4
作者：
Ho, DDM;London, R;Young, DA
通讯作者：
Young, DA