Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?
Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?
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DOI：
10.1371/journal.pone.0045166
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Shiels PG
中科院分区：
文献类型：
--
作者：
Der G;Batty GD;Benzeval M;Deary IJ;Green MJ;McGlynn L;McIntyre A;Robertson T;Shiels PG
到目前为止，寻找衰老的生物标记物(BOAS)在很大程度上是不成功的，人们普遍对找到任何满足美国老龄研究联合会制定的标准的生物标记物的前景持怀疑态度。这可能是因为标准过于严格，也可能是因为综合衡量标准可能更合适。作为BoA的候选基因，端粒长度引起了人们的极大关注。我们调查它是否符合被认为是衰老的单一生物标志物的标准，以及它是否对综合衡量标准做出了有用的贡献。使用大量基于人群的研究数据，我们发现端粒长度与年龄有关，与身体和认知功能的几个指标有关，与正常衰老有关，与总体健康的三个指标有关。在大多数情况下，端粒长度增加了年龄的预测能力，尽管总体上它并不是一个很好的预测指标。我们使用主成分分析从功能指标中形成了两个组合，一个包括端粒长度，另一个不包括端粒长度。这些综合BOA比实际年龄更能预测健康结果。这两种复合材料之间的差异不大。端粒长度不满足BoA的严格标准，但确实增加了对时间年龄的预测能力。先前研究的模棱两可的结果可能是由于缺乏力量或选择了一起检查的方法，而只关注单一的生物标志物。复合生物标记物具有超越年龄的潜力，应该被考虑用于这一领域的未来研究。
The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research. This may be because the criteria are too strict or because a composite measure might be more appropriate. Telomere length has attracted a great deal of attention as a candidate BoA. We investigate whether it meets the criteria to be considered as a single biomarker of aging, and whether it makes a useful contribution to a composite measure. Using data from a large population based study, we show that telomere length is associated with age, with several measures of physical and cognitive functioning that are related to normal aging, and with three measures of overall health. In the majority of cases, telomere length adds predictive power to that of age, although it was not nearly as good a predictor overall. We used principal components analysis to form two composites from the measures of functioning, one including telomere length and the other not including it. These composite BoAs were better predictors of the health outcomes than chronological age. There was little difference between the two composites. Telomere length does not satisfy the strict criteria for a BoA, but does add predictive power to that of chronological age. Equivocal results from previous studies might be due to lack of power or the choice of measures examined together with a focus on single biomarkers. Composite biomarkers of aging have the potential to outperform age and should be considered for future research in this area.
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DOI：
10.1093/gerona/glq050
发表时间：
2010-08-01
影响因子：
5.1
作者：
Mather, Karen Anne;Jorm, Anthony Francis;Christensen, Helen
通讯作者：
Christensen, Helen
影响因子：
7.2
作者：
Miilunpalo, S;Vuori, I;Urponen, H
通讯作者：
Urponen, H
影响因子：
5.3
作者：
Bendix L;Gade MM;Staun PW;Kimura M;Jeune B;Hjelmborg JV;Aviv A;Christensen K
通讯作者：
Christensen K
影响因子：
2.5
作者：
Harris, Sarah E.;Deary, Ian J.;Shiels, Paul G.
通讯作者：
Shiels, Paul G.
影响因子：
5
作者：
Idler, EL;Benyamini, Y
通讯作者：
Benyamini, Y