Progression of cardio-metabolic risk factors in subjects born small and large for gestational age.
Progression of cardio-metabolic risk factors in subjects born small and large for gestational age.
复制标题
DOI：
10.1371/journal.pone.0104278
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Mohn A
中科院分区：
文献类型：
--
作者：
Chiavaroli V;Marcovecchio ML;de Giorgis T;Diesse L;Chiarelli F;Mohn A
出生时小于胎龄儿（SGA）和大于胎龄儿（LGA）的受试者在青春期前已经具有增加的心脏代谢改变风险。然而，他们从童年到青春期的心脏代谢特征的进展尚未得到充分探讨。我们的目的是评估出生SGA和LGA的受试者与出生适合胎龄（阿加）的受试者相比，从儿童期到青春期心脏代谢谱的潜在变化。这项纵向研究包括35名阿加、24名SGA和31名LGA受试者，在儿童期（平均年龄（±SD）8.4±1.4岁）进行评估，然后在青春期（平均年龄13.3±1.8岁）进行重新评估。评估BMI、血压、胰岛素抵抗（空腹胰岛素，HOMA-IR）和血脂。应用心脏代谢风险z评分，包括计算BMI、血压、HOMA-IR、甘油三酯和甘油三酯：高密度脂蛋白胆固醇比的性别特异性z评分总和。SGA组和LGA组儿童期（均P<0.01）和青春期（均P<0.01）空腹胰岛素和HOMA-IR均高于阿加组。类似地，SGA和LGA儿童的聚集性心脏代谢风险评分高于阿加儿童（均P<0.05），并且组间差异在青春期增加（均P<0.05）。值得注意的是，在SGA和LGA受试者中，从儿童期到青春期观察到聚集性心脏代谢风险评分的进展（均P<0.05）。与阿加同龄人相比，SGA和LGA受试者在儿童期表现出不良的心脏代谢特征，在青春期这种特征恶化。这些发现表明，SGA和LGA人群中胰岛素抵抗和总体估计心血管风险从儿童期到青春期随时间推移而进展。
Subjects born small (SGA) and large (LGA) for gestational age have an increased risk of cardio-metabolic alterations already during prepuberty. Nevertheless, the progression of their cardio-metabolic profile from childhood to adolescence has not been fully explored. Our aim was to assess potential changes in the cardio-metabolic profile from childhood to adolescence in subjects born SGA and LGA compared to those born appropriate (AGA) for gestational age. This longitudinal study included 35 AGA, 24 SGA and 31 LGA subjects evaluated during childhood (mean age (±SD) 8.4±1.4 yr) and then re-assessed during adolescence (mean age 13.3±1.8 yr). BMI, blood pressure, insulin resistance (fasting insulin, HOMA-IR) and lipids were assessed. A cardio-metabolic risk z-score was applied and this consisted in calculating the sum of sex-specific z-scores for BMI, blood pressure, HOMA-IR, triglycerides and triglycerides:high-density lipoprotein cholesterol ratio. Fasting insulin and HOMA-IR were higher in SGA and LGA than AGA subjects both during childhood (all P<0.01) and adolescence (all P<0.01). Similarly, the clustered cardio-metabolic risk score was higher in SGA and LGA than AGA children (both P<0.05), and these differences among groups increased during adolescence (both P<0.05). Of note, a progression of the clustered cardio-metabolic risk score was observed from childhood to adolescence within SGA and within LGA subjects (both P<0.05). SGA and LGA subjects showed an adverse cardio-metabolic profile during childhood when compared to AGA peers, with a worsening of this profile during adolescence. These findings indicate an overtime progression of insulin resistance and overall estimated cardiovascular risk from childhood to adolescence in SGA and LGA populations.
登录
查看更多内容
影响因子：
16.2
作者：
Giannini C;Santoro N;Caprio S;Kim G;Lartaud D;Shaw M;Pierpont B;Weiss R
通讯作者：
Weiss R
胰岛素抵抗和脂联素水平与青春期前中国小于胎龄个体的身高追赶性生长有关
影响因子：
4.5
作者：
Deng HZ;Deng H;Su Z;Li YH;Ma HM;Chen HS;Du ML
通讯作者：
Du ML
影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
影响因子：
--
作者：
Andersen, Lars B.;Sardinha, Luis B.;Andersen, Sigmund A.
通讯作者：
Andersen, Sigmund A.
影响因子：
3.6
作者：
Bugge, Anna;El-Naaman, Bianca;Andersen, Lars Bo
通讯作者：
Andersen, Lars Bo