Striatal networks for tinnitus treatment targeting.
Striatal networks for tinnitus treatment targeting.
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DOI：
10.1002/hbm.25676
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发表时间：
2022-02-01
影响因子：
4.8
通讯作者：
Cheung SW
中科院分区：
文献类型：
--
作者：
Hinkley LBN;Larson PS;Henderson Sabes J;Mizuiri D;Demopoulos C;Adams ME;Neylan TC;Hess CP;Nagarajan SS;Cheung SW
采用以个性化纹状体网络或功能连接图为指导的目标选择方法，神经调节治疗恼人耳鸣的效果可能更大，更可预测。几种皮质纹状体机制可能在耳鸣中起作用，包括背/腹侧纹状体和壳核。我们研究了尾状核深部脑刺激（DBS）对耳鸣的显著治疗反应是否与纹状体网络增加的耳鸣网络功能连接有关，纹状体网络涉及听觉皮层或小脑腹侧。第一项研究采用横断面2 × 2因子设计（耳鸣，无耳鸣；听力损失，听力正常，n = 68），使用7.0 T静息状态功能磁共振成像（fMRI）定义队列水平异常功能连接图。第二项研究是一个试验性病例-对照系列（n = 2），目的是研究尾状尾再分化刺激对耳鸣的调节反应是否取决于个体水平纹状体连接图与耳鸣网络的关系。静息状态fMRI发现了5个尾状核分支，它们具有异常的队列水平功能连接图。其中，两张连接图显示出与耳鸣网络的连接增加——背尾状头与Heschl回和尾状尾与腹侧小脑。与没有耳鸣调节的无应答者相比，病例系列应答者的尾状尾DBS导致耳鸣严重程度和响度的显着降低。应答者的个体水平连接图与队列期望连接图一致，其中尾状尾与耳鸣网络的连接增加，而无应答者的个体水平连接图则没有。通过采用个性化纹状体网络或功能连接图指导的目标选择方法，可能更容易实现对令人烦恼的耳鸣的神经调节。在这里，我们提出了一项两方面的fMRI研究（队列研究和病例对照研究），表明在一个大的耳鸣患者队列和一个神经调性DBS应答患者中，尾状核皮质-小脑连通性增加。
Neuromodulation treatment effect size for bothersome tinnitus may be larger and more predictable by adopting a target selection approach guided by personalized striatal networks or functional connectivity maps. Several corticostriatal mechanisms are likely to play a role in tinnitus, including the dorsal/ventral striatum and the putamen. We examined whether significant tinnitus treatment response by deep brain stimulation (DBS) of the caudate nucleus may be related to striatal network increased functional connectivity with tinnitus networks that involve the auditory cortex or ventral cerebellum. The first study was a cross‐sectional 2‐by‐2 factorial design (tinnitus, no tinnitus; hearing loss, normal hearing, n = 68) to define cohort level abnormal functional connectivity maps using high‐field 7.0 T resting‐state fMRI. The second study was a pilot case–control series (n = 2) to examine whether tinnitus modulation response to caudate tail subdivision stimulation would be contingent on individual level striatal connectivity map relationships with tinnitus networks. Resting‐state fMRI identified five caudate subdivisions with abnormal cohort level functional connectivity maps. Of those, two connectivity maps exhibited increased connectivity with tinnitus networks—dorsal caudate head with Heschl's gyrus and caudate tail with the ventral cerebellum. DBS of the caudate tail in the case‐series responder resulted in dramatic reductions in tinnitus severity and loudness, in contrast to the nonresponder who showed no tinnitus modulation. The individual level connectivity map of the responder was in alignment with the cohort expectation connectivity map, where the caudate tail exhibited increased connectivity with tinnitus networks, whereas the nonresponder individual level connectivity map did not. Successful neuromodulation for bothersome tinnitus may more attainable by adopting a target selection approach guided by personalized striatal networks or functional connectivity maps. Here, we present a two‐pronged fMRI study (cohort and case–control) demonstrating increased caudate‐corticocerebellar connectivity in both a large cohort of tinnitus sufferers and a single patient that was a neuromodulatory DBS responder.
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DOI：
10.1073/pnas.1018466108
发表时间：
2011-05-17
影响因子：
11.1
作者：
De Ridder, Dirk;Elgoyhen, Ana Belen;Langguth, Berthold
通讯作者：
Langguth, Berthold
影响因子：
2.9
作者：
Cheng, Shirui;Xu, Guixing;Liang, Fanrong
通讯作者：
Liang, Fanrong
DOI：
10.3109/03005368909077819
发表时间：
1989-01-01
期刊：
British Journal of Audiology
影响因子：
--
作者：
AXELSSON A;RINGDAHL A
通讯作者：
RINGDAHL A
影响因子：
1.8
作者：
Eggermont, Jos J.
通讯作者：
Eggermont, Jos J.
影响因子：
2.8
作者：
Canlon, Barbara;Theorell, Tores;Hasson, Dan
通讯作者：
Hasson, Dan