pH-responsive superstructures prepared via the assembly of Fe(3)O(4) amphipathic Janus nanoparticles.
pH-responsive superstructures prepared via the assembly of Fe(3)O(4) amphipathic Janus nanoparticles.
复制标题
通过组装 Fe3O4 两亲性 Janus 纳米颗粒制备 pH 响应性超结构
DOI：
10.1093/rb/rby016
复制
发表时间：
2018-10
影响因子：
6.7
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Cai S;Luo B;Zhan X;Zhou X;Lan F;Yi Q;Wu Y
提出了利用Fe 3 O 4两亲性Janus纳米粒子（Fe3O4@AJNPs）负载β-环糊精（β-CD）和氨基吡啶（APD）功能化的聚甲基丙烯酸甲酯（PGMA），通过β-CD和APD之间的主客体相互作用构建pH响应性共组装体的策略。平均粒径约为210 nm的球形共组装体具有优异的磁响应性，并且在去离子水中稳定长达2个月。这些共组装体的pH值可靠的能力，揭示了通过拆卸所形成的超结构的破坏建成的包合物。用扫描电镜、透射电镜、动态光散射和荧光分子探针等手段对脱附过程进行了监测。当APD中氮的质子化导致的共组装体解体后，由于疏水性的PGMA-APD与Fe3O4@AJNPs分子链之间缺乏相互作用，剩余的Fe3O4@AJNPs分子开始重新组装形成自组装体。此外，可回收的Fe3O4@APJNs可以与PGMA-APD多次组装，形成具有均匀形貌的共组装体。这些pH敏感的共组装体具有高稳定性、良好的磁响应性和细胞相容性，可用作pH响应载体，其中包封药物用于随后的控制释放。
The strategy of using Fe3O4 amphiphilic Janus nanoparticles (Fe3O4@AJNPs) bearing β-cyclodextrin (β-CD) and aminopyridine (APD) functionalized polymethyl methacrylate (PGMA) to construct pH-stimuli responsive co-assemblies through host-guest interactions between β-CD and APD was proposed. The spherical co-assemblies with an average diameter about 210 nm were excellent magnetic responsive and quite stable even up to 2 months in deionized water. The pH-liable capability of these co-assemblies was revealed by disassembly of the formed superstructures with destruction of the built inclusion complexes. The disassembly process was monitored by SEM, TEM, DLS and fluorescent molecules probe. After disassembly of the co-assemblies caused by protonation of nitrogens in APD, hydrophobic PGMA-APD lacking of interactions with the Fe3O4@AJNPs chains was precipitated, and the remained Fe3O4@AJNPs turned to re-assemble to self-assemblies. Besides, the recyclable Fe3O4@APJNs could reassembly with additional PGMA-APD to build co-assemblies with a uniform morphology for several times. These pH-sensitive co-assemblies with high stability, good magnetic responsiveness and cytocompatibility could be used as pH-responsive vehicles within which to encapsulate drugs for subsequent controlled release.
登录
查看更多内容
影响因子：
4.4
作者：
TWEET, AG;GAINES, GL;BELLAMY, WD
通讯作者：
BELLAMY, WD
DOI：
10.1016/j.jpba.2007.01.054
发表时间：
2007-05-09
影响因子：
3.4
作者：
Crupi, V.;Ficarra, R.;Venuti, V.
通讯作者：
Venuti, V.
DOI：
10.1039/f29767201525
发表时间：
1976-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS II
影响因子：
--
作者：
ISRAELACHVILI, JN;MITCHELL, DJ;NINHAM, BW
通讯作者：
NINHAM, BW
影响因子：
6.7
作者：
Groschel, Andre H.;Mueller, Axel H. E.
通讯作者：
Mueller, Axel H. E.
影响因子：
3.4
作者：
Ruditskiy, Aleksey;Ren, Bin;Kretzschmar, Ilona
通讯作者：
Kretzschmar, Ilona