Epithelial regulation of mesenchymal tissue behavior.
Epithelial regulation of mesenchymal tissue behavior.
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DOI：
10.1038/jid.2010.420
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发表时间：
2011-04
影响因子：
6.5
通讯作者：
Mustoe, Thomas A.
中科院分区：
文献类型：
--
作者：
Gallant-Behm, Corrie L.;Du, Pan;Ln, Simon M.;Marucha, Philip T.;DiPietro, Luisa A.;Mustoe, Thomas A.
Fibroproliferative scars are an important clinical problem, and yet the mechanisms which regulate scar formation remain poorly understood. This study explored the hypothesis that the epidermis plays a critical role in dictating scar formation, and that those interactions differ in skin and mucosa. Paired skin and vaginal mucosal wounds on NZW rabbits diverged significantly; the cutaneous epithelium exhibited a greater and prolonged response to injury as compared to the mucosa. Microarray analysis of the injured epithelium was performed, and numerous factors were identified which were more strongly upregulated in skin, including several pro-inflammatory cytokines and pro-fibrotic growth factors. Analysis of the underlying mesenchymal tissue demonstrated a fibrotic response in the dermis of the skin but not the mucosal lamina propria, in the absence of a connective tissue injury. To determine if the pro-inflammatory factors produced by the epidermis may have a role in dermal fibrosis, an interleukin-1 receptor antagonist was administered locally to healing skin wounds. In the NZW rabbit model, blockade of interleukin-1 signaling was effective in preventing hypertrophic scar formation. These results support the idea that soluble factors produced by the epithelium in response to injury may influence fibroblast behavior and regulate scar formation in vivo.
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影响因子：
6.5
作者：
MaasSzabowski, N;Fusenig, NE
通讯作者：
Fusenig, NE
影响因子：
2.9
作者：
Cole, J;Tsou, R;Isik, F
通讯作者：
Isik, F
影响因子：
6.1
作者：
Basson, MD
通讯作者：
Basson, MD
影响因子：
2.2
作者：
Chang, CC;Kuo, YF;Jee, SH
通讯作者：
Jee, SH
影响因子：
14.9
作者：
CORPET, F
通讯作者：
CORPET, F