The Role of Vitamin D in COVID-19 and the Impact of Pandemic Restrictions on Vitamin D Blood Content.
The Role of Vitamin D in COVID-19 and the Impact of Pandemic Restrictions on Vitamin D Blood Content.
复制标题
DOI：
10.3389/fphar.2022.836738
复制
发表时间：
2022
影响因子：
5.6
通讯作者：
Kubiak JZ
中科院分区：
文献类型：
--
作者：
Tomaszewska A;Rustecka A;Lipińska-Opałka A;Piprek RP;Kloc M;Kalicki B;Kubiak JZ
维生素D是一种调节免疫系统的激素，在应对微生物感染方面发挥着关键作用。它通过影响巨噬细胞、T细胞和树突状细胞中免疫应答基因的转录来调节炎症过程。维生素D在许多呼吸道感染性疾病中的作用已得到证实，这表明维生素D也应该在SARS-CoV-2感染中发挥作用。维生素D通过将促炎性Th 1和Th 17转换为抗炎性Th 2和Treg反应来抑制细胞因子风暴。因此，维生素D有望在预防、缓解症状或治疗SARS-CoV-2感染症状（包括严重肺炎）方面发挥作用。维生素D可能通过几种可能的机制降低COVID-19感染的风险，例如诱导cathelicidin和防御素的转录。还报道了维生素D和与维生素D密切相关的分子光甾醇的非基因组抗病毒作用。尽管取得了巨大进展，但目前仍没有足够的科学证据支持补充维生素D可能有助于治疗COVID-19感染的说法。大流行的限制也被证明通过限制暴露在阳光下来影响维生素D的吸收。
Vitamin D is a hormone regulating the immune system and playing a pivotal role in responses to microbial infections. It regulates inflammatory processes by influencing the transcription of immune-response genes in macrophages, T cells, and dendritic cells. The proven role of vitamin D in many infectious diseases of the respiratory tract indicated that vitamin D should also play a role in SARS-CoV-2 infection. Vitamin D inhibits cytokine storm by switching the pro-inflammatory Th1 and Th17 to the anti-inflammatory Th2 and Treg response. Vitamin D is therefore expected to play a role in preventing, relieving symptoms, or treating SARS-CoV-2 infection symptoms, including severe pneumonia. There are several possible mechanisms by which vitamin D may reduce the risk of COVID-19 infection, such as induction of the transcription of cathelicidin and defensin. Also a nongenomic antiviral action of vitamin D and lumisterol, the molecule closely related to vitamin D, was reported. Despite this enormous progress, currently, there is still insufficient scientific evidence to support the claim that vitamin D supplementation may help treat COVID-19 infection. The pandemic restrictions were also shown to impact vitamin D uptake by limiting exposure to sunlight.
登录
查看更多内容
影响因子：
4.1
作者：
Elamir YM;Amir H;Lim S;Rana YP;Lopez CG;Feliciano NV;Omar A;Grist WP;Via MA
通讯作者：
Via MA
每日高剂量口服维生素 D 治疗对 COVID 19 疾病患者炎症标志物的影响。
影响因子：
4.6
作者：
Lakkireddy M;Gadiga SG;Malathi RD;Karra ML;Raju ISSVPM;Ragini;Chinapaka S;Baba KSSS;Kandakatla M
通讯作者：
Kandakatla M
影响因子：
--
作者：
Hansdottir, Sif;Monick, Martha M.
通讯作者：
Monick, Martha M.
维生素 D 与神经系统疾病： 内分泌观点。
影响因子：
5.6
作者：
Di Somma C;Scarano E;Barrea L;Zhukouskaya VV;Savastano S;Mele C;Scacchi M;Aimaretti G;Colao A;Marzullo P
通讯作者：
Marzullo P
DOI：
10.1007/s10072-020-04801-y
发表时间：
2020-12
期刊：
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
影响因子：
--
作者：
Favas TT;Dev P;Chaurasia RN;Chakravarty K;Mishra R;Joshi D;Mishra VN;Kumar A;Singh VK;Pandey M;Pathak A
通讯作者：
Pathak A