Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice.
Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice.
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DOI：
10.1016/j.yebeh.2010.05.006
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Comi AM
中科院分区：
文献类型：
--
作者：
Kadam SD;Smith-Hicks CL;Smith DR;Worley PF;Comi AM
发育中的大脑中风是慢性神经系统疾病（包括神经行为功能障碍和癫痫）的重要原因。在这里，我们描述了一个小鼠模型的新生儿中风造成的单侧颈动脉结扎，导致急性癫痫发作，长期多动症，自发性偏侧盘旋行为，认知功能受损和癫痫。在海马神经元中立即早期基因Arc（活性调节细胞骨架相关蛋白）的探索依赖性诱导在神经元的一般群体中与在缺血损伤后约1周产生并用BrdU标记的神经元中进行了检查。虽然弧诱导的网络特定的方式后，严重的新生儿中风，它受损，不仅在同侧受伤，但也在对侧未受伤的campi检查时，在6个月后的新生儿中风。中风损伤的严重程度和获得性中风后癫痫，都与电弧感应和新的神经元整合到功能回路中受伤的大脑中动脉呈负相关。
Stroke in the developing brain is an important cause of chronic neurological morbidities including neurobehavioral dysfunction and epilepsy. Here, we describe a mouse model of neonatal stroke resulting from unilateral carotid ligation that results in acute seizures, long-term hyperactivity, spontaneous lateralized circling behavior, impaired cognitive function and epilepsy. Exploration-dependent induction of immediate early gene, Arc (activity-regulated cytoskeleton associated protein) in hippocampal neurons was examined in the general population of neurons versus neurons that were generated ~ 1week after the ischemic insult and labeled with BrdU. Although Arc was inducible in a network specific manner after severe neonatal stroke, it was impaired, not only in the ipsilateral injured but also in the contralateral uninjured hippocampi when examined at 6 months after the neonatal stroke. Severity of the stroke-injury and the acquired post-stroke epilepsy, both negatively correlated with Arc-induction and new neuron integration into functional circuits in the injured hippocampi.
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影响因子：
4.2
作者：
Kadam, S. D.;Mulholland, J. D.;McDonald, J. W.;Comi, A. M.
通讯作者：
Comi, A. M.
影响因子：
2.9
作者：
Kadam, S. D.;Mulholland, J. D.;Comi, A. M.
通讯作者：
Comi, A. M.
影响因子：
--
作者：
Burneo, JG;Faught, E;Kuzniecky, R
通讯作者：
Kuzniecky, R
影响因子：
2.2
作者：
Hellier, JL;Dudek, FE
通讯作者：
Dudek, FE
影响因子：
5.3
作者：
Lindemann, S;Lessenich, A;Löscher, W
通讯作者：
Löscher, W