Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccine antibody prevalence in a multi-ethnic inner-city antenatal population: A cross-sectional surveillance study.
Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccine antibody prevalence in a multi-ethnic inner-city antenatal population: A cross-sectional surveillance study.
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DOI：
10.1111/1471-0528.17508
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发表时间：
2023-08
影响因子：
5.8
通讯作者：
Poston, Lucilla
中科院分区：
文献类型：
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作者：
Andreeva, Daria;Gill, Carolyn;Brockbank, Anna;Hejmej, Joanna;Conti-Ramsden, Fran J.;Doores, Katie T.;Seed, Paul;Poston, Lucilla
确定内城地区妊娠期严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）血清阳性率，并评估与人口统计学因素和疫苗接种时间的相关性。重复横断面监测研究。伦敦妇产中心。2020年7月至2022年1月，共有906名孕妇接受颈部扫描。检测血液样本中针对SARS-CoV-2核衣壳（N）和刺突（S）蛋白的IgG抗体。记录自我报告的疫苗接种状态和2019冠状病毒病（COVID-19）感染情况。多变量回归模型确定与血清阳性率和抗体滴度相关的人口统计学因素。免疫球蛋白G N和S蛋白抗体滴度。在960名女性中，196名（20.4%）是先前感染的SARS-CoV-2血清阳性。其中，70例（35.7%）自我报告既往感染。在未接种疫苗的女性中，黑人种族背景的女性最有可能是SARS-CoV-2血清阳性（与白色调整的风险比[aRR] 1.88，95% CI 1.35-2.61，p < 0.001）。来自黑人和混合种族背景的女性最不可能有S蛋白血清阳性疫苗接种史（与白色相比，aRR 0.58，95%CI 0.40-0.84，p = 0.004; aRR 0.56，95%CI 0.34-0.92，p = 0.021）。双重接种疫苗的既往感染女性的IgG S蛋白抗体滴度高于未接种疫苗的既往感染女性（平均差异4.76倍变化，95% CI 2.65-6.86，p < 0.001）。妊娠前与妊娠期间接种疫苗的时间不影响IgG S抗体滴度（平均差异-0.28倍变化，95% CI-2.61至2.04，p = 0.785）。这项横断面研究表明，黑人种族背景的女性无症状SARS-CoV-2感染率较高，感染风险较高，疫苗接种率较低。SARS-CoV-2抗体滴度在双重接种的感染女性中最高。 本文包括作者见解，视频摘要可在：https：//emckclac-my.sharepoint.com/：v：/g/personal/k1888594_kcl_ac_uk/ESBeVJ 8VdMtMtDOaAflgfLIBoKJ 6 i7 g8 v-OkeQEc 8 cyTnA？e=v3fXo8。
To determine severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) seroprevalence in pregnancy in an inner‐city setting and assess associations with demographic factors and vaccination timing. Repeated cross‐sectional surveillance study. London maternity centre. A total of 906 pregnant women attending nuchal scans, July 2020–January 2022. Blood samples were tested for IgG antibodies against SARS‐CoV‐2 nucleocapsid (N) and spike (S) proteins. Self‐reported vaccination status and coronavirus disease 2019 (COVID‐19) infection were recorded. Multivariable regression models determined demographic factors associated with seroprevalence and antibody titres. Immunoglobulin G N‐ and S‐protein antibody titres. Of the 960 women, 196 (20.4%) were SARS‐CoV‐2 seropositive from previous infection. Of these, 70 (35.7%) self‐reported previous infection. Among unvaccinated women, women of black ethnic backgrounds were most likely to be SARS‐CoV‐2 seropositive (versus white adjusted risk ratio [aRR] 1.88, 95% CI 1.35–2.61, p < 0.001). Women from black and mixed ethnic backgrounds were least likely to have a history of vaccination with seropositivity to S‐protein (versus white aRR 0.58, 95% CI 0.40–0.84, p = 0.004; aRR 0.56, 95% CI 0.34–0.92, p = 0.021, respectively). Double vaccinated, previously infected women had higher IgG S‐protein antibody titres than unvaccinated, previously infected women (mean difference 4.76 fold‐change, 95% CI 2.65–6.86, p < 0.001). Vaccination timing before versus during pregnancy did not affect IgG S‐antibody titres (mean difference −0.28 fold‐change, 95% CI −2.61 to 2.04, p = 0.785). This cross‐sectional study demonstrates high rates of asymptomatic SARS‐CoV‐2 infection with women of black ethnic backgrounds having higher infection risk and lower vaccine uptake. SARS‐CoV‐2 antibody titres were highest among double‐vaccinated, infected women. This article includes Author Insights, a video abstract available at: https://emckclac‐my.sharepoint.com/:v:/g/personal/k1888594_kcl_ac_uk/ESBeVJ8VdMtMtDOaAflgfLIBoKJ6i7g8v‐OkeQEc8cyTnA?e=v3fXo8.
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DOI：
10.1016/j.bbi.2021.03.008
发表时间：
2021-05
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Robertson E;Reeve KS;Niedzwiedz CL;Moore J;Blake M;Green M;Katikireddi SV;Benzeval MJ
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影响因子：
9.8
作者：
Blakeway H;Prasad S;Kalafat E;Heath PT;Ladhani SN;Le Doare K;Magee LA;O'Brien P;Rezvani A;von Dadelszen P;Khalil A
通讯作者：
Khalil A
影响因子：
4.6
作者：
Abba-Aji M;Stuckler D;Galea S;McKee M
通讯作者：
McKee M
DOI：
10.1016/j.ijid.2021.01.013
发表时间：
2021-03
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
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作者：
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癌症患者对COVID-19的疫苗接种后的血清转化率 - 系统评价。
DOI：
10.1016/j.annonc.2021.10.014
发表时间：
2022-03
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
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作者：
Corti C;Antonarelli G;Scotté F;Spano JP;Barrière J;Michot JM;André F;Curigliano G
通讯作者：
Curigliano G