Inhibition of transcription of herpes simplex virus immediate early genes in interferon-treated human cells.
Inhibition of transcription of herpes simplex virus immediate early genes in interferon-treated human cells.
复制标题
干扰素处理的人类细胞中单纯疱疹病毒立即早期基因转录的抑制。
DOI：
10.1099/0022-1317-69-6-1167
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
A. Panet
中科院分区：
文献类型：
--
作者：
F. Oberman;A. Panet
The effect of interferon (IFN) treatment on the early stages of herpes simplex virus type 1 (HSV-1) replication in three types of human cells was investigated. Interferon pretreatment was shown to reduce the steady state levels of both total and polysomebound HSV-1 immediate early alpha mRNAs. Using the nuclear run-off transcription assay, we showed that IFN selectively inhibited transcription of the HSV-1 genes, with no effect on transcription of total cellular RNA or that of the beta-tubulin RNA. Thus, IFN appears to inhibit the initiation of HSV-1 alpha gene transcription rather than affect the stability of the respective mRNAs. IFN did not prevent the HSV-1-induced early shut-off of host cellular protein synthesis caused by a structural protein of infecting virus. This observation indicated that the IFN-mediated inhibition of HSV-1 replication is at a stage beyond viral penetration into the cytoplasm. These results suggested that IFN blocked HSV-1 replication primarily at a very early stage, during the onset of alpha mRNA transcription.
疱疹病毒大分子合成的调节：转录起始位点和α基因的结构域。
DOI：
10.1073/pnas.77.12.7122
发表时间：
1980
影响因子：
11.1
作者：
Mackem,S;Roizman,B
通讯作者：
Roizman,B
DOI：
10.1073/pnas.83.2.256
发表时间：
1986-01-01
影响因子：
11.1
作者：
GODOWSKI, PJ;KNIPE, DM
通讯作者：
KNIPE, DM
影响因子：
5.3
作者：
M. P. Quinlan;D. Knipe
通讯作者：
M. P. Quinlan;D. Knipe