ExoCarta 2012: database of exosomal proteins, RNA and lipids.

ExoCarta 2012: database of exosomal proteins, RNA and lipids.
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DOI:
10.1093/nar/gkr828
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发表时间:
2012-01
影响因子:
14.9
通讯作者:
Simpson RJ
Simpson RJ
中科院分区:
生物学2区
文献类型:
--
作者:
Mathivanan S;Fahner CJ;Reid GE;Simpson RJ

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外泌体是由来自不同生物体的大多数细胞类型释放的内吞来源的膜状纳米囊泡;它们在细胞间通讯中起关键作用。ExoCarta(http://www.example.com)是一个人工管理的外泌体蛋白、RNA和脂质数据库。该数据库收录了来自已发表和未发表的外泌体研究的信息。外泌体纯化和表征的模式、生物物理和分子性质列于数据库中,帮助生物医学科学家评估外泌体制备的质量和获得的相应数据。目前,ExoCarta(3.1版)包含来自134个外泌体研究的11261个蛋白质条目、2375个mRNA条目和764个miRNA条目的信息。除了数据更新之外,作为一项新功能,ExoCarta还添加了在外来体中识别的脂质。我们相信,这个免费的基于网络的社区资源将帮助研究人员识别特定于某些组织/细胞类型来源的外泌体的分子特征(蛋白质/RNA/脂质),并引发新的外泌体研究。
Exosomes are membraneous nanovesicles of endocytic origin released by most cell types from diverse organisms; they play a critical role in cell–cell communication. ExoCarta (http://www.exocarta.org) is a manually curated database of exosomal proteins, RNA and lipids. The database catalogs information from both published and unpublished exosomal studies. The mode of exosomal purification and characterization, the biophysical and molecular properties are listed in the database aiding biomedical scientists in assessing the quality of the exosomal preparation and the corresponding data obtained. Currently, ExoCarta (Version 3.1) contains information on 11 261 protein entries, 2375 mRNA entries and 764 miRNA entries that were obtained from 134 exosomal studies. In addition to the data update, as a new feature, lipids identified in exosomes are added to ExoCarta. We believe that this free web-based community resource will aid researchers in identifying molecular signatures (proteins/RNA/lipids) that are specific to certain tissue/cell type derived exosomes and trigger new exosomal studies.
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