Nociceptors: a phylogenetic view.
Nociceptors: a phylogenetic view.
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伤害感受器：系统发育视图。
DOI：
10.1007/s00359-009-0482-z
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发表时间：
2009-12
影响因子：
2.1
通讯作者：
Lewin, Gary R.
中科院分区：
文献类型：
--
作者：
Smith, Ewan St. John;Lewin, Gary R.
对环境变化作出反应的能力对于生物体的生存至关重要，而一个基本的先决条件是能够检测和应对令人厌恶的刺激。大多数动物都有专门的感觉传入神经，它们对伤害性刺激做出反应，称为伤害感受器，这一事实说明了拥有一个内置的“检测和保护”系统的重要性。如果发生损伤，则通常存在致敏，由此增加的伤害感受器敏感性和/或伤害感受器相关神经回路的可塑性充当受影响的身体部位的保护机制。研究不同模式生物的伤害感受和伤害感受器已经证明，从无脊椎动物到人类都有相似之处。基因操纵生物体，特别是小鼠的技术的发展，导致了对伤害感受器功能中一些关键分子的理解。这篇评论将集中在什么是已知的伤害感受器在整个动物界和什么相似之处存在跨门，特别是在离子通道的分子水平。
The ability to react to environmental change is crucial for the survival of an organism and an essential prerequisite is the capacity to detect and respond to aversive stimuli. The importance of having an inbuilt “detect and protect” system is illustrated by the fact that most animals have dedicated sensory afferents which respond to noxious stimuli called nociceptors. Should injury occur there is often sensitization, whereby increased nociceptor sensitivity and/or plasticity of nociceptor-related neural circuits acts as a protection mechanism for the afflicted body part. Studying nociception and nociceptors in different model organisms has demonstrated that there are similarities from invertebrates right through to humans. The development of technology to genetically manipulate organisms, especially mice, has led to an understanding of some of the key molecular players in nociceptor function. This review will focus on what is known about nociceptors throughout the Animalia kingdom and what similarities exist across phyla; especially at the molecular level of ion channels.
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影响因子：
2.5
作者：
BILLY, AJ;WALTERS, ET
通讯作者：
WALTERS, ET
DOI：
10.1523/jneurosci.3795-08.2008
发表时间：
2008-12-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Binshtok AM;Wang H;Zimmermann K;Amaya F;Vardeh D;Shi L;Brenner GJ;Ji RR;Bean BP;Woolf CJ;Samad TA
通讯作者：
Samad TA
影响因子：
29.4
作者：
Brierley, SM;Jones, RCW;Blackshaw, LA
通讯作者：
Blackshaw, LA
影响因子：
9.2
作者：
Al-Anzi, Bader;Tracey, W. Daniel, Jr.;Benzer, Seymour
通讯作者：
Benzer, Seymour
影响因子：
2.5
作者：
BYRNE, J;CASTELLU.V;KANDEL, ER
通讯作者：
KANDEL, ER