Estrogen, the Peripheral Immune System and Major Depression - A Reproductive Lifespan Perspective.
Estrogen, the Peripheral Immune System and Major Depression - A Reproductive Lifespan Perspective.
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DOI：
10.3389/fnbeh.2022.850623
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
重度抑郁症是影响全世界数百万人的重大医学问题。几十年来，人们一直在对导致其表现的因素进行深入研究，并发现了包括性激素和免疫系统在内的几个目标。事实上，大量的文献已经证明性激素在调节大脑功能和影响心理健康方面发挥着关键作用，尤其是在雌性生物中。新的研究结果还表明，重度抑郁症的炎症病因学，揭示了补充甚至取代目前在一些患者群体中可用的药物干预的新机会。鉴于免疫系统的性别差异和性激素水平波动对女性免疫系统的深远影响，探讨内分泌、神经和免疫系统如何共同影响女性的心理健康是有必要的。在这里，我们回顾了内源性雌激素和外源性雌激素治疗对情感和免疫的影响，并在女性生命周期中不同的生殖里程碑的背景下讨论了这些观察结果。为心理健康和重度抑郁症的进一步研究提供了理论框架和重要考虑因素。
Major depression is a significant medical issue impacting millions of individuals worldwide. Identifying factors contributing to its manifestation has been a subject of intense investigation for decades and several targets have emerged including sex hormones and the immune system. Indeed, an extensive body of literature has demonstrated that sex hormones play a critical role in modulating brain function and impacting mental health, especially among female organisms. Emerging findings also indicate an inflammatory etiology of major depression, revealing new opportunities to supplement, or even supersede, currently available pharmacological interventions in some patient populations. Given the established sex differences in immunity and the profound impact of fluctuations of sex hormone levels on the immune system within the female, interrogating how the endocrine, nervous, and immune systems converge to impact women’s mental health is warranted. Here, we review the impacts of endogenous estrogens as well as exogenously administered estrogen-containing therapies on affect and immunity and discuss these observations in the context of distinct reproductive milestones across the female lifespan. A theoretical framework and important considerations for additional study in regards to mental health and major depression are provided.
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影响因子：
--
作者：
Walf AA;Frye CA
通讯作者：
Frye CA
影响因子：
64.5
作者：
Brodin P;Jojic V;Gao T;Bhattacharya S;Angel CJ;Furman D;Shen-Orr S;Dekker CL;Swan GE;Butte AJ;Maecker HT;Davis MM
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Davis MM
影响因子：
5.3
作者：
Brachman, Rebecca A.;Lehmann, Michael L.;Herkenham, Miles
通讯作者：
Herkenham, Miles
影响因子：
2.9
作者：
BERNARDI, M;VERGONI, AV;BERTOLINI, A
通讯作者：
BERTOLINI, A
影响因子：
16.6
作者：
Abolins S;King EC;Lazarou L;Weldon L;Hughes L;Drescher P;Raynes JG;Hafalla JCR;Viney ME;Riley EM
通讯作者：
Riley EM