Harmonic Distortion of Blood Pressure Waveform as a Measure of Arterial Stiffness.
Harmonic Distortion of Blood Pressure Waveform as a Measure of Arterial Stiffness.
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DOI：
10.3389/fbioe.2022.842754
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发表时间：
2022
影响因子：
5.7
通讯作者：
Zhang, Yanhang
中科院分区：
文献类型：
--
作者：
Milkovich, Nicholas;Gkousioudi, Anastasia;Seta, Francesca;Suki, Bela;Zhang, Yanhang
衰老和疾病会改变主动脉壁的成分和弹性特性，导致血压波形 (BPW) 的形状发生变化。在这里，我们提出了一个新的指数，谐波失真（HD），来表征 BPW 及其与其他体外和体内测量的关系。使用 BPW 的傅立叶变换，HD 计算为基频以上的能量与基频处的能量之比。使用正常饮食 (ND) 或高脂肪、高蔗糖 (HFHS) 饮食 2-10 个月的雄性小鼠来研究饮食诱发的代谢综合征中的 BPW。使用无线电遥测技术，在 24 小时内每小时记录 20 秒 BPW。脉搏波速度（PWV）是动脉僵硬度的一种体内测量方法，通过超声检查在腹主动脉中测量。从一组小鼠中切除颈总动脉，以使用双轴张力充气试验测定切线模量。在 24 小时内，HD 和收缩压 (SBP) 均表现出较大的变异性，但 HD 随着 SBP 的增加而线性下降。 HD 也与切线模量和 PWV 呈线性相关，且两个饮食组之间的斜率显着不同。总体而言，我们的研究表明 HD 对血压和动脉僵硬度的变化敏感，并且有潜力用作衰老和疾病中动脉僵硬度的无创测量。
Aging and disease alter the composition and elastic properties of the aortic wall resulting in shape changes in blood pressure waveform (BPW). Here, we propose a new index, harmonic distortion (HD), to characterize BPW and its relationship with other in vitro and in vivo measures. Using a Fourier transform of the BPW, HD is calculated as the ratio of energy above the fundamental frequency to that at the fundamental frequency. Male mice fed either a normal diet (ND) or a high fat, high sucrose (HFHS) diet for 2–10 months were used to study BPWs in diet-induced metabolic syndrome. BPWs were recorded for 20 s hourly for 24 h, using radiotelemetry. Pulse wave velocity (PWV), an in vivo measure of arterial stiffness, was measured in the abdominal aorta via ultrasound sonography. Common carotid arteries were excised from a subset of mice to determine the tangent modulus using biaxial tension-inflation test. Over a 24-h period, both HD and systolic blood pressure (SBP) show a large variability, however HD linearly decreases with increasing SBP. HD is also linearly related to tangent modulus and PWV with slopes significantly different between the two diet groups. Overall, our study suggests that HD is sensitive to changes in blood pressure and arterial stiffness and has a potential to be used as a noninvasive measure of arterial stiffness in aging and disease.
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影响因子：
5.7
作者：
Gkousioudi A;Yu X;Ferruzzi J;Qian J;Wainford RD;Seta F;Zhang Y
通讯作者：
Zhang Y
DOI：
10.1186/1532-429x-12-10
发表时间：
2010-03-05
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Hayashi K;Mani V;Nemade A;Aguiar S;Postley JE;Fuster V;Fayad ZA
通讯作者：
Fayad ZA
影响因子：
8.3
作者：
Blacher, J;Asmar, R;Safar, ME
通讯作者：
Safar, ME
影响因子：
4.9
作者：
Gatzka, CD;Kingwell, BA;Dart, AM
通讯作者：
Dart, AM
影响因子：
3.4
作者：
Chow, Ming-Jay;Turcotte, Raphael;Zhang, Yanhang
通讯作者：
Zhang, Yanhang