Recent advances in brown adipose tissue biology

Recent advances in brown adipose tissue biology
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棕色脂肪组织生物学的最新进展

DOI:
10.1007/s11434-014-0386-3
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发表时间:
2014-05
影响因子:
--
通讯作者:
Jin W
Jin W
中科院分区:
--
文献类型:
--
作者:
Lin J;Zhao Q;Lee H-J;Jin W

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在哺乳动物中,白色脂肪组织(WAT)储存能量,而棕色脂肪组织(BAT)燃烧能量。作为一种产热器官,BAT可以在寒冷暴露期间帮助维持体温。由于其在能量代谢和调节三酰甘油水平方面的重要作用,BAT在治疗肥胖及其相关疾病方面受到了极大的关注。最近的研究表明,BAT可能会分泌因子--蝙蝠素--来调节全身的能量代谢。本文综述了BAT的形成和功能,以及调节BAT和米色脂肪活性的分子的最新进展。
In mammals, white adipose tissue (WAT) store energy, whereas brown adipose tissue (BAT) burns energy. As a thermogenic organ, BAT can help maintain body temperature during cold exposure. Owing to its important roles in energy metabolism and regulating triacylglycerol levels, BAT has received great attention in treating obesity and its related diseases. Recent studies have suggested that BAT may secrete factor(s)—batokines—to regulate whole-body energy metabolism. In this review, we summarize the recent advances in the formation and function of BAT, as well as molecules that regulate the activity of BAT and beige fat.
DOI: 10.3181/00379727-183-42414
发表时间: 1986-11
影响因子: --
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