Mechanisms of parent-child transmission of tobacco and alcohol use with polygenic risk scores: Evidence for a genetic nurture effect.
Mechanisms of parent-child transmission of tobacco and alcohol use with polygenic risk scores: Evidence for a genetic nurture effect.
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DOI：
10.1037/dev0001028
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发表时间：
2021-05
影响因子：
4
通讯作者：
GWAS & Sequencing Consortium of Alcohol and Nicotine Use (GSCAN)
中科院分区：
文献类型：
--
作者：
Saunders GRB;Liu M;Vrieze S;McGue M;Iacono WG;GWAS & Sequencing Consortium of Alcohol and Nicotine Use (GSCAN)
亲子相似性是遗传和环境传递的函数。此外，未传递给后代的遗传效应可能会驱动父母的行为，从而影响孩子的养育环境。通过多基因风险评分（PRS）直接测量遗传倾向，提供了一种方法来测试非传播的父母基因型对后代结果的影响，称为“遗传养育”效应。换句话说，父母的基因组是否以及如何通过环境影响他们的孩子。目前的研究使用多基因风险评分吸烟开始，每天吸烟和每周饮酒来预测3，008对双胞胎的样本中的物质使用，从17岁到29岁进行前瞻性评估，他们的父母来自明尼苏达州双胞胎和家庭研究中心。混合效应模型被用来测试遗传教养效应，即父母的PRS预测后代烟草和酒精的使用后，统计调整后代自己的PRS。父母开始吸烟PRS预测了24岁时的每日吸烟量（β=0.103; 95%置信区间（CI）[0.03，0.17]）和17岁时的饮酒量（β=0.091; 95% CI [0.04，0.14]），与共同遗传无关。父母的PRS与17岁时的后代吸烟之间也存在暗示性的独立关联（β=0.096; 95%CI [0.02，0.17]）。中介分析提供了一些证据，父母吸烟，饮酒和家庭社会经济地位的环境影响。这些发现，以及更广泛地使用的分子遗传学方法，对确定环境对物质使用等发育结果的影响具有影响。
Parent-child similarity is a function both of genetic and environmental transmission. In addition, genetic effects not transmitted to offspring may drive parental behavior, thereby affecting the rearing environment of the child. Measuring genetic proclivity directly, through polygenic risk scores (PRSs), provides a way to test for the effect of non-transmitted parental genotype, on offspring outcome, termed a “genetic nurture” effect. In other words, if and how parental genomes might affect their children through the environment. The current study used polygenic risk scores for smoking initiation, cigarettes per day, and drinks per week to predict substance use in a sample of 3,008 twins, assessed prospectively from age 17 to age 29, and their parents, from the Minnesota Center for Twin and Family Research. Mixed effects models were used to test for a genetic nurture effect whereby parental PRSs predict offspring tobacco and alcohol use after statistically adjusting for offspring’s own PRS. Parental smoking initiation PRS predicted offspring cigarettes per day at age 24 (β=0.103; 95% confidence interval (CI) [0.03, 0.17]) and alcohol use at age 17 (β=0.091; 95% CI [0.04, 0.14]) independent of shared genetics. There was also a suggestive independent association between the parent PRS and offspring smoking at age 17 (β=0.096; 95% CI [0.02, 0.17]). Mediation analyses provided some evidence for environmental effects of parental smoking, alcohol use, and family socioeconomic status. These findings, and more broadly the molecular genetic method used, have implications on the identification of environmental effects on developmental outcomes such as substance use.
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影响因子：
0.9
作者：
Miller, Michael B.;Basu, Saonli;Cunningham, Julie;Eskin, Eleazar;Malone, Steven M.;Oetting, William S.;Schork, Nicholas;Sul, Jae Hoon;Iacono, William G.;McGue, Matt
通讯作者：
McGue, Matt
影响因子：
6.3
作者：
Gilman, SE;Abrams, DB;Buka, SL
通讯作者：
Buka, SL
明尼苏达双胞胎家庭研究的富集研究：增加了外部化精神病理风险高风险的双胞胎家族的产量。
DOI：
10.1375/twin.12.5.489
发表时间：
2009-10
期刊：
Twin research and human genetics : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Keyes MA;Malone SM;Elkins IJ;Legrand LN;McGue M;Iacono WG
通讯作者：
Iacono WG
影响因子：
8
作者：
Gilman SE;Rende R;Boergers J;Abrams DB;Buka SL;Clark MA;Colby SM;Hitsman B;Kazura AN;Lipsitt LP;Lloyd-Richardson EE;Rogers ML;Stanton CA;Stroud LR;Niaura RS
通讯作者：
Niaura RS
影响因子：
56.9
作者：
Kong, Augustine;Thorleifsson, Gudmar;Stefansson, Kari
通讯作者：
Stefansson, Kari