Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies.
Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies.
复制标题
跟腱生物学：利用肌腱发育、愈合和再生的机制来推进治疗策略。
DOI：
10.1002/dvdy.269
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Galloway JL
中科院分区：
文献类型：
--
作者：
Tsai SL;Nödl MT;Galloway JL
肌腱是专门的富含基质的结缔组织，其将力从肌肉传递到骨骼，并且对于运动至关重要。作为经常传递大的机械载荷的组织，肌腱在所有年龄段的患者中都是常见的损伤。损伤后，哺乳动物肌腱愈合不良，通过一个缓慢的过程，形成混乱的纤维化瘢痕组织与较差的生物力学功能。目前的治疗方法是有限的，患者可能会留下一个较弱的肌腱，可能会再次断裂，并增加发展退行性疾病的机会。需要更有效的替代治疗。然而，我们目前对肌腱生物学的了解仍然有限。在这里，我们强调为什么扩大我们对肌腱发育，愈合和再生的知识对于推进肌腱再生医学至关重要。我们提供了一个全面的审查，目前的机制支配肌腱的发展和愈合，并进一步强调再生肌腱模型，包括新生小鼠和斑马鱼最近的工作。重要的是，我们讨论了如何将目前和未来的发现应用于增强目前的治疗和设计新的策略来治疗肌腱损伤。
Tendons are specialized matrix-rich connective tissues that transmit forces from muscle to bone and are essential for movement. As tissues that frequently transfer large mechanical loads, tendons are commonly injured in patients of all ages. Following injury, mammalian tendons heal poorly through a slow process that forms disorganized fibrotic scar tissue with inferior biomechanical function. Current treatments are limited and patients can be left with a weaker tendon that is likely to re-rupture and an increased chance of developing degenerative conditions. More effective, alternative treatments are needed. However, our current understanding of tendon biology remains limited. Here, we emphasize why expanding our knowledge of tendon development, healing, and regeneration is imperative for advancing tendon regenerative medicine. We provide a comprehensive review of the current mechanisms governing tendon development and healing and further highlight recent work in regenerative tendon models including the neonatal mouse and zebrafish. Importantly, we discuss how present and future discoveries can be applied to both augment current treatments and design novel strategies to treat tendon injuries.
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DOI：
10.1126/science.1242281
发表时间：
2014-06-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Blanpain C;Fuchs E
通讯作者：
Fuchs E
影响因子：
82.9
作者：
Bi, Yanming;Ehirchiou, Driss;Young, Marian F.
通讯作者：
Young, Marian F.
影响因子：
4.8
作者：
Best, Katherine T.;Loiselle, Alayna E.
通讯作者：
Loiselle, Alayna E.
影响因子：
2.4
作者：
Bell, Rebecca;Li, Jun;Wang, Vincent M.
通讯作者：
Wang, Vincent M.
影响因子：
7.7
作者：
Ackerman, Jessica E.;Nichols, Anne E. C.;Loiselle, Alayna E.
通讯作者：
Loiselle, Alayna E.