Low serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study.
Low serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study.
复制标题
低血清维生素 D 浓度与肥胖相关，但与瘦 NAFLD 无关：一项横断面研究
DOI：
10.1186/s12937-021-00690-9
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发表时间：
2021-04-01
影响因子：
5.4
通讯作者：
Xu C
中科院分区：
文献类型：
--
作者：
Wang Q;Shi X;Wang J;Zhang J;Xu C
背景低血清维生素D浓度已被报道与非酒精性脂肪性肝病（NAFLD）的风险增加有关;然而，瘦或肥胖个体是否显示维生素D与NAFLD之间的类似关联仍然是推测性的。本研究旨在探讨血清维生素D浓度与瘦型和肥胖型中国成年人NAFLD的关系。方法本横断面研究纳入了2019年在浙江大学医学院附属第一医院进行健康体检的2538名参与者（男性1360名，女性1178名）。排除其他原因，通过肝脏超声诊断NAFLD。血清维生素D浓度与NAFLD的关联进行了分析，在瘦和肥胖的participant.ResultsThe NAFLD的总患病率为33.61%（13.10%，瘦和53.32%，肥胖）在这项研究的人口。肥胖NAFLD患者血清维生素D水平低于非肥胖NAFLD对照组。然而，瘦NAFLD患者的血清维生素D水平与瘦NAFLD对照组相当。血清维生素D水平与肥胖者NAFLD的患病率呈负相关，但与瘦型参与者无关。血清维生素D水平与肥胖受试者的NAFLD风险独立相关，校正比值比（95%CI）为0.987（0.981-0.993）。然而，血清维生素D水平是不相关的风险NAFLD瘦participator.ConclusionsA低血清维生素D水平与NAFLD肥胖，但不瘦的参与者。
BackgroundA low serum vitamin D concentration has been reported to be associated with an increased risk of non-alcoholic fatty liver disease (NAFLD); however, whether lean or obese individuals show a similar association between vitamin D and NAFLD remains speculative. This study aimed to explore the relationship between serum vitamin D concentration and NAFLD in lean and obese Chinese adults.MethodsThis cross-sectional study included 2538 participants (1360 men and 1178 women) who underwent health checkups at the First Affiliated Hospital, Zhejiang University School of Medicine in 2019. NAFLD was diagnosed by liver ultrasound excluding other causes. The association of serum vitamin D concentration with NAFLD was analyzed in lean and obese participants.ResultsThe overall prevalence of NAFLD was 33.61% (13.10% in lean and 53.32% in obese) in this study population. The serum vitamin D levels of obese NAFLD patients were lower than those of obese NAFLD-free controls. However, the serum vitamin D levels of lean NAFLD patients were comparable to those of lean NAFLD-free controls. Serum vitamin D level was negatively correlated with the prevalence of NAFLD in obese but not lean participants. Serum vitamin D level was independently associated with the risk of NAFLD in obese participants, with an adjusted odds ratio (95% CI) of 0.987 (0.981–0.993). However, serum vitamin D level was not related to the risk of NAFLD in lean participants.ConclusionsA low serum vitamin D level is associated with NAFLD in obese but not lean participants.
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影响因子：
1.9
作者：
Akyuz, Umit;Yesil, Atakan;Yilmaz, Yusuf
通讯作者：
Yilmaz, Yusuf
影响因子：
15.8
作者：
Jarvis, Helen;Craig, Dawn;Hanratty, Barbara
通讯作者：
Hanratty, Barbara
DOI：
10.1016/j.numecd.2012.12.006
发表时间：
2013-08
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Jablonski KL;Jovanovich A;Holmen J;Targher G;McFann K;Kendrick J;Chonchol M
通讯作者：
Chonchol M
血清维生素 D 与体重和肝酶正常的中国男性非酒精性脂肪肝相关
影响因子：
8.2
作者：
Hao, Ya-ping;Ma, Xiao-jing;Jia, Wei-ping
通讯作者：
Jia, Wei-ping
影响因子：
5.9
作者：
Keane JT;Elangovan H;Stokes RA;Gunton JE
通讯作者：
Gunton JE