Age-specific associations with dental caries in HIV-infected, exposed but uninfected and HIV-unexposed uninfected children in Nigeria.
Age-specific associations with dental caries in HIV-infected, exposed but uninfected and HIV-unexposed uninfected children in Nigeria.
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DOI：
10.1186/s12903-022-02421-w
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发表时间：
2022-09-27
期刊：
影响因子：
2.9
通讯作者：
Coker MO
中科院分区：
文献类型：
--
作者：
Akhigbe P;Chukwumah NM;Folayan MO;Divaris K;Obuekwe O;Omoigberale A;Jedy-Agba E;Kim M;Charurat ME;Richards VP;Coker MO
艾滋病毒感染及其管理给受影响的个人带来了巨大的健康负担，并与口腔和牙科疾病的风险增加有关。在这项研究中，我们试图量化4-11岁尼日利亚儿童乳牙和恒牙列中与艾滋病毒相关的龋齿患病率和严重程度的差异。我们使用的临床、实验室、人口统计学和行为数据来自一项正在进行的队列研究，研究对象包括年龄匹配的HIV感染（HI，n = 181）、HIV暴露但未感染（HEU，n = 177）和HIV未暴露和未感染（HUU，n = 186）儿童。龋齿经历的测量（即，患病率和严重程度）基于由经过培训和校准的临床检查者记录的dmft/DMFT指数。使用多变量logistic和负二项回归模型估计HI、HEU和HUU之间的乳牙和恒牙龋齿经历的差异。HI儿童患龋率（33%）显著高于HEU（15%）和HUU（22%）儿童。这种差异在完全校正的分析中持续存在[比值比（OR）= 1.6; 95%置信区间（CI）= 1.0-2.6]，在恒牙列中最明显（OR = 3.4; 95% CI = 1.2-9.5），并反映了龋齿严重程度的差异。虽然磨牙在乳牙列和恒牙列中均受到主要影响，但不同牙列的龋齿病变模式有所不同。龋齿严重程度与乳牙发育不良、牙龈炎症和较低的CD 4计数显著相关。我们发现，HI儿童中龋齿的患病率和严重程度较高，这是由于与未感染的儿童相比，恒牙列龋齿的负担增加。在这项研究中确定的牙列特定的协会强调需要设计和实施特定年龄的龋齿预防策略。这些措施可能包括强化口腔卫生方案，旨在减轻HI儿童中唾液过少的致龋影响。同样，乳牙和恒牙釉质发育缺陷的长期影响也不容忽视。在线版本包含补充材料，可通过10.1186/s12903-022-02421-w获得。
HIV infection and its management confer a substantial health burden to affected individuals and have been associated with increased risk of oral and dental diseases. In this study, we sought to quantify HIV-associated differences in the prevalence and severity of dental caries in the primary and permanent dentition of 4–11-year-old Nigerian Children. We used clinical, laboratory, demographic, and behavioral data obtained from an ongoing cohort study of age-matched HIV-infected (HI, n = 181), HIV-exposed-but-uninfected (HEU, n = 177), and HIV-unexposed-and-uninfected (HUU, n = 186) children. Measures of dental caries experience (i.e., prevalence and severity) were based on dmft/DMFT indices recorded by trained and calibrated clinical examiners. Differences in primary and permanent dentition caries experience between HI, HEU, and HUU were estimated using multivariable logistic and negative binomial regression modeling. HI children had significantly higher caries experience (33%) compared to HEU (15%) and HUU (22%) children. This difference persisted in fully adjusted analyses [odds ratio (OR) = 1.6; 95% confidence interval (CI) = 1.0–2.6], was most pronounced in the permanent dentition (OR = 3.4; 95% CI = 1.2–9.5), and mirrored differences in caries severity. While molars were predominantly affected in both primary and permanent dentitions, caries lesion patterns differed between dentitions. Caries severity was significantly associated with hypoplastic primary teeth, gingival inflammation, and lower CD4 counts. We found that the higher prevalence and severity of dental caries among HI children was driven by increased burden of permanent dentition caries compared to their uninfected counterparts. The dentition-specific associations identified in this study highlight the need to design and implement age-specific caries prevention strategies. These may include intensified oral hygiene regimens aimed at mitigating the cariogenic impact of hyposalivation among HI children. Similarly, the long-lasting impacts of developmental defects of the enamel in the primary and permanent dentitions must not be ignored. The online version contains supplementary material available at 10.1186/s12903-022-02421-w.
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DOI：
10.1590/1678-77572016-0021
发表时间：
2017-01
期刊：
Journal of applied oral science : revista FOB
影响因子：
--
作者：
Charone S;Portela MB;Martins KO;Soares RM;Castro GF
通讯作者：
Castro GF
影响因子：
6
作者：
Golin R;Samuel JM;Phelps BR;Persaud U;Malati CY;Siberry GK
通讯作者：
Siberry GK
影响因子：
4.6
作者：
Griffen, Ann L.;Thompson, Zachary A.;Fidel, Paul L., Jr.
通讯作者：
Fidel, Paul L., Jr.
DOI：
10.4103/npmj.npmj_7_17
发表时间：
2017-01-01
期刊：
The Nigerian postgraduate medical journal
影响因子：
--
作者：
Adeniyi, Abiola A;Odusanya, Olumuyiwa O
通讯作者：
Odusanya, Olumuyiwa O
影响因子：
2.9
作者：
Kalanzi, Dunstan;Mayanja-Kizza, Harriet;Sewankambo, Nelson K.
通讯作者：
Sewankambo, Nelson K.