Prevalence of self-reported diabetes and exposure to organochlorine pesticides among Mexican Americans: Hispanic health and nutrition examination survey, 1982-1984.
Prevalence of self-reported diabetes and exposure to organochlorine pesticides among Mexican Americans: Hispanic health and nutrition examination survey, 1982-1984.
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DOI：
10.1289/ehp.10258
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发表时间：
2007-12
影响因子：
10.4
通讯作者：
Marcus M
中科院分区：
文献类型：
--
作者：
Cox S;Niskar AS;Narayan KM;Marcus M
墨西哥裔美国人的糖尿病患病率高于非西班牙裔白人。据报道，墨西哥裔美国人的血清有机氯农药水平较高。很少有研究探索农药暴露与糖尿病之间的联系。我们开始研究1982年至1984年居住在美国西南部的墨西哥裔美国人中自我报告的糖尿病与血清有机氯杀虫剂浓度之间的关系。这项研究是在西班牙裔健康和营养检查调查中对1303名年龄在20-74岁的墨西哥裔美国人进行的。在至少1%的研究人群中，有7种农药或农药代谢物的血清浓度处于可量化水平：p，p‘-滴滴涕(二氯二苯基三氯乙烷)、p，p’-滴滴涕(二氯二苯基二氯乙烯)、狄氏剂、环氧氯丹、β-六氯环己烷、六氯苯和反式十一氯。我们使用Logistic回归来评估在调整和不调整总血脂的情况下，自我报告的糖尿病与暴露于有机氯农药之间的关系。比较各接触组的非空腹血糖值。自我报告的糖尿病与血清中反式九氯、环氧氯丹和β-六氯环己烷水平超过可检测限值，以及接触p，p‘-滴滴涕和p，p’-滴滴涕水平最高的人显著相关。在调整总血脂方面，与p，p‘-DDT的相关性仍然显著。暴露于反式橙花胺和β-六氯环己烷的人群中，血糖水平升高。这项研究表明，某些有机氯农药的血清水平较高可能与糖尿病患病率的增加有关。需要进行更广泛的临床评估的更多研究来证实这种联系。
The prevalence of diabetes is higher among Mexican Americans than among non-Hispanic whites. Higher serum levels of organochlorine pesticides in Mexican Americans have been reported. Few studies have explored the association between pesticide exposure and diabetes. We set out to examine the association between self-reported diabetes and serum concentrations of organochlorine pesticides among Mexican Americans residing in the southwestern United States from 1982 to 1984. This study was conducted among a sample of 1,303 Mexican Americans 20–74 years of age from the Hispanic Health and Nutrition Examination Survey. Serum concentrations were available for seven pesticides or pesticide metabolites at quantifiable levels in at least 1% of the study population: p,p′-DDT (dichlorodiphenyltrichloroethane), p,p′-DDE (dichlorodiphenyldichloro-ethylene), dieldrin, oxychlordane, β-hexachlorocyclohexane, hexachlorobenzene, and trans-nonachlor. We used logistic regression to evaluate the association of self-reported diabetes with exposure to organochlorine pesticides, with and without adjustment for total serum lipids. Nonfasting serum glucose values were compared among exposure groups. Self-reported diabetes was significantly associated with serum levels above the detectable limit for trans-nonachlor, oxychlordane, and β-hexachlorocyclohexane and among those with the highest level of exposure to p,p′-DDT and p,p′-DDE. On adjustment for total serum lipids, the association with p,p′-DDT remained significant. Serum glucose levels were elevated among those exposed to trans-nonachlor and β-hexachlorocyclohexane. This study suggests that higher serum levels of certain organochlorine pesticides may be associated with increased prevalence of diabetes. Additional studies with more extensive clinical assessment are needed to confirm this association.
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影响因子：
120.7
作者：
Narayan, KMV;Boyle, JP;Williamson, DF
通讯作者：
Williamson, DF
DOI：
10.1080/00039896.1967.10664995
发表时间：
1967-01-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
LAWS, ER;CURLEY, A;BIROS, FJ
通讯作者：
BIROS, FJ
影响因子：
5.4
作者：
Longnecker, MP;Michalek, JE
通讯作者：
Michalek, JE
影响因子：
10.4
作者：
Laden, F;Neas, LM;Hunter, DJ
通讯作者：
Hunter, DJ
影响因子：
16.2
作者：
FLEGAL, KM;EZZATI, TM;STERN, MP
通讯作者：
STERN, MP