Evaluation of Touchscreen Chambers To Assess Cognition in Adult Mice: Effect of Training and Mild Traumatic Brain Injury.
Evaluation of Touchscreen Chambers To Assess Cognition in Adult Mice: Effect of Training and Mild Traumatic Brain Injury.
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评估触摸屏室以评估成年小鼠的认知：训练和轻度创伤性脑损伤的效果。
DOI：
10.1089/neu.2017.4998
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发表时间：
2017
影响因子：
4.2
通讯作者：
Floyd,CandaceL
中科院分区：
文献类型：
--
作者：
Nichols,JessicaN;Hagan,KentonL;Floyd,CandaceL
轻度创伤性脑损伤（mTBI）后通常会出现认知障碍。在临床竞技场中，神经心理学评估经常用于检测认知缺陷。然而，mTBI的动物模型依赖于各种各样的行为任务来评估认知结果。基于计算机的触摸屏系统已被开发用于啮齿动物，并被假设为提供一种翻译方法来评估认知功能，因为在啮齿动物中执行的任务与在人类中执行的任务相似。虽然这些触摸屏系统已用于神经退行性疾病和精神障碍的临床前模型，但尚未研究它们在评估mTBI后的认知障碍中的用途。我们假设mTBI会导致触摸屏任务的认知表现受损，特别是那些具有基于屏幕的学习组件的任务，包括配对联想学习（PAL）任务和位置辨别（LD）任务。成年雄性C57 BL/6小鼠接受单次冲击加速mTBI。我们发现，在受伤前训练小鼠达到标准是艰巨的，而且表现对许多环境变量很敏感。尽管进行了广泛的优化和训练，但小鼠在PAL范式中的表现未能优于机会。或者，小鼠在LD范式中表现出一定的学习能力，但仅限于任务的较容易阶段。然而，mTBI并不影响LD范例中的表现。因此，我们得出结论，在这里提出的条件下，PAL和LD触摸屏任务不是用于评价单次冲击加速度mTBI后C57 BL/6小鼠认知性能的稳健结果指标。
Cognitive impairments are often experienced after a mild traumatic brain injury (mTBI). In the clinical arena, neuropsychological assessments are used frequently to detect cognitive deficits. Animal models of mTBI, however, rely on an assortment of behavioral tasks to assess cognitive outcome. Computer-based touchscreen systems have been developed for rodents and are hypothesized to offer a translational approach to evaluate cognitive function because of the similarities of tasks performed in rodents to those implemented in humans. While these touchscreen systems have been used in pre-clinical models of neurodegenerative diseases and psychiatric disorders, their use in assessing cognitive impairment after mTBI has not been investigated. We hypothesized that mTBI would result in impaired cognitive performance on touchscreen tasks, particularly those with hippocampal-based learning components, including the paired associate learning (PAL) task and the location discrimination (LD) task. Adult male, C57BL/6 mice received a single impact-acceleration mTBI. We found that training mice before injury to perform to criteria is arduous and that performance is sensitive to many environmental variables. Despite extensive optimization and training, mice failed to perform better than chance in the PAL paradigm. Alternatively, mice demonstrated some capacity to learn in the LD paradigm, but only with the easier stages of the task. The mTBI did not affect performance in the LD paradigm, however. Thus, we concluded that under the conditions presented here, the PAL and LD touchscreen tasks are not robust outcome measures for the evaluation of cognitive performance in C57BL/6 mice after a single impact-acceleration mTBI.
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影响因子：
3.4
作者：
Luo J;Nguyen A;Villeda S;Zhang H;Ding Z;Lindsey D;Bieri G;Castellano JM;Beaupre GS;Wyss-Coray T
通讯作者：
Wyss-Coray T
探索轻度创伤性脑损伤的血清生物标志物
影响因子：
64.8
作者：
L. Papa;Damyan Edwards;Michelle M. Ramia
通讯作者：
Michelle M. Ramia
影响因子：
3.7
作者：
Lederle L;Weber S;Wright T;Feyder M;Brigman JL;Crombag HS;Saksida LM;Bussey TJ;Holmes A
通讯作者：
Holmes A
影响因子：
3.7
作者：
Delotterie D;Mathis C;Cassel JC;Dorner-Ciossek C;Marti A
通讯作者：
Marti A
影响因子：
2.9
作者：
GORMAN, LK;SHOOK, BL;BECKER, DP
通讯作者：
BECKER, DP