Innate immune cells are dispensable for regenerative growth of imaginal discs
Innate immune cells are dispensable for regenerative growth of imaginal discs
复制标题
先天免疫细胞对于成虫盘的再生生长是可有可无的
DOI：
10.1016/j.mod.2012.11.005
复制
发表时间：
2013
影响因子：
2.6
通讯作者：
Katsuyama
中科院分区：
文献类型：
--
作者：
Katsuyama
Following tissue damage the immune response, including inflammation, has been considered an inevitable condition to build the host defense against invading pathogens. The recruitment of innate immune leukocytes to injured tissue is observed in both vertebrates and invertebrates. However, it is still not conclusive whether the inflammatory response is also indispensable for the wound healing process by itself, in addition to its role in microbial clearance. In this study we determine the requirement of innate immune cells, both hemocytes and fat body cells, in Drosophila imaginal disc regeneration. We investigate wound healing and regenerative cell proliferation of damaged imaginal discs under immunodeficient conditions. To delay development of Drosophila at matured third instar larval stage we used a sterol-mutant erg2 knock-out yeast strain in the medium. This dietary-controlled developmental arrest allowed us to generate larvae free of immune cells without interfering with their larval development. In addition, this approach allowed uncoupling regenerative cell proliferation of damaged discs from their normal developmental growth. We furthermore examined the regenerative cell proliferation of fragmented imaginal discs by transplantation into host flies deficient of immune cells. We demonstrate that the damaged/fragmented discs in immune cells deficient conditions still exhibit regenerative cell proliferation comparable to those of control samples. These results suggest that recruitment of immune cells is not a prerequisite for the regenerative growth of damaged imaginal discs.
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DOI：
10.1155/2011/176802
发表时间：
2011
期刊：
Cholesterol
影响因子：
--
作者：
Niwa R;Niwa YS
通讯作者：
Niwa YS
果蝇成虫腿盘模式调节过程中的区室限制和芽基形成。
影响因子：
2.7
作者：
Louise C. Abbott;G. Karpen;G. Schubiger
通讯作者：
G. Schubiger
酿酒酵母 erg-2 和 erg-6 甾醇突变株上黑腹果蝇的生长停滞
DOI：
--
发表时间：
1986
期刊：
影响因子：
--
作者：
C. Parkin;B. Burnet
通讯作者：
B. Burnet
影响因子：
2.7
作者：
K. McClure;Anne Sustar;G. Schubiger
通讯作者：
K. McClure;Anne Sustar;G. Schubiger
DOI：
10.1007/bf00848779
发表时间：
1977-01-01
期刊：
WILHELM ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY
影响因子：
--
作者：
HAYNIE, JL;BRYANT, PJ
通讯作者：
BRYANT, PJ