The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS.
The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS.
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DOI：
10.1002/glia.22389
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发表时间：
2013-01
期刊：
影响因子：
6.2
通讯作者：
Stevens, Beth
中科院分区：
文献类型：
--
作者：
Schafer, Dorothy P.;Lehrman, Emily K.;Stevens, Beth
小胶质细胞是中枢神经系统（CNS）的常驻免疫细胞和吞噬细胞。虽然大多数工作都集中在CNS疾病和损伤期间小胶质细胞的快速和强大的反应，但新出现的证据表明，这些神秘的细胞在健康，完整的CNS中的CNS突触中具有重要作用。在麻醉的成年小鼠中进行的开创性活体成像研究表明，小胶质细胞过程动态地观察它们的环境，并与其他脑细胞（包括神经元和星形胶质细胞）相互作用。最近的成像研究表明，小胶质细胞动态地与突触相互作用，它们似乎充当“突触传感器”，响应神经活动和神经递质释放的变化。在下面的综述中，我们讨论了最近的工作表明，小胶质细胞在发育和成熟的突触发挥积极作用。我们首先讨论了重要的成像研究，使我们更好地了解健康大脑中小胶质细胞和突触之间的物理关系。在此讨论之后，我们回顾了已知的分子机制和小胶质细胞-突触相互作用在发育和成熟的中枢神经系统的功能后果。我们目前的知识揭示了这些神秘细胞在健康CNS中突触发育和功能的关键功能，但也引发了一些新的有趣的问题，仍有待探索。我们讨论这些开放的问题，以及如何在健康的中枢神经系统的最新发现可能与异常和/或神经回路的损失相关的病理。
Microglia are the resident immune cells and phagocytes of our central nervous system (CNS). While most work has focused on the rapid and robust responses of microglia during CNS disease and injury, emerging evidence suggests that these mysterious cells have important roles at CNS synapses in the healthy, intact CNS. Groundbreaking live imaging studies in the anesthetized, adult mouse demonstrated that microglia processes dynamically survey their environment and interact with other brain cells including neurons and astrocytes. More recent imaging studies have revealed that microglia dynamically interact with synapses where they appear to serve as “synaptic sensors,” responding to changes in neural activity and neurotransmitter release. In the following review, we discuss the most recent work demonstrating that microglia play active roles at developing and mature synapses. We first discuss the important imaging studies that have led us to better understand the physical relationship between microglia and synapses in the healthy brain. Following this discussion, we review known molecular mechanisms and functional consequences of microglia-synapse interactions in the developing and mature CNS. Our current knowledge sheds new light on the critical functions of these mysterious cells in synapse development and function in the healthy CNS, but has also incited several new and interesting questions that remain to be explored. We discuss these open questions, and how the most recent findings in the healthy CNS may be related to pathologies associated with abnormal and/or loss of neural circuits.
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影响因子：
2.7
作者：
Bilbo, SD;Rudy, JW;Maier, SF
通讯作者：
Maier, SF
影响因子：
--
作者：
Cullheim, Staffan;Thams, Sebastian
通讯作者：
Thams, Sebastian
DOI：
10.1007/bf00325030
发表时间：
1968-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
BLINZING.K;KREUTZBE.G
通讯作者：
KREUTZBE.G
影响因子：
16.2
作者：
Datwani, Akash;McConnell, Michael J.;Kanold, Patrick O.;Micheva, Kristina D.;Busse, Brad;Shamloo, Mehrdad;Smith, Stephen J.;Shatz, Carla J.
通讯作者：
Shatz, Carla J.
影响因子：
5.3
作者：
Belmonte, MK;Allen, G;Webb, SJ
通讯作者：
Webb, SJ