Learning to see: patterned visual activity and the development of visual function.

Learning to see: patterned visual activity and the development of visual function.
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DOI:
10.1016/j.tins.2010.01.003
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发表时间:
2010-04
影响因子:
15.9
通讯作者:
Aizenman, Carlos D.
Aizenman, Carlos D.
中科院分区:
医学1区
文献类型:
--
作者:
Ruthazer, Edward S.;Aizenman, Carlos D.

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为了成功地与环境相互作用,发育中的生物体需要正确地处理感官信息,并产生与其大小和结构相适应的运动输出。人们早就知道,模式化的感觉体验会诱导各种形式的发育可塑性,最终形成成熟的神经回路。然而,这些相同类型的可塑性也允许发育中的有机体通过动态地调整神经回路功能以适应大脑回路和感觉输入的持续变化来适当地对外部世界做出反应。最近对青蛙和鱼类视觉系统的研究为视觉体验如何在多个层面上动态影响电路功能提供了前所未有的视角,从基因表达到网络功能,最终导致系统范围的功能适应。
To successfully interact with their environment, developing organisms need to correctly process sensory information and generate motor output appropriate to their size and structure. Patterned sensory experience has long been known to induce various forms of developmental plasticity which ultimately shape mature neural circuits. Yet these same types of plasticity also allow developing organisms to respond appropriately to the external world by dynamically adapting neural circuit function to ongoing changes in brain circuitry and sensory input. Recent work on the visual system of frogs and fish has provided an unprecedented view into how visual experience dynamically affects circuit function at many levels, ranging from gene expression to network function, ultimately leading to system-wide functional adaptations.
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