Anti-hepatitis B virus X protein in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV.
Anti-hepatitis B virus X protein in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV.
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DOI：
10.1155/2009/289068
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发表时间：
2009
影响因子：
--
通讯作者：
Zhang XD
中科院分区：
文献类型：
--
作者：
Zhang H;Wu LY;Zhang S;Qiu LY;Li N;Zhang X;Zhang XZ;Shan CL;Ye LH;Zhang XD
B型肝炎病毒X蛋白（HBx）在肝细胞癌（HCC）的发生发展中起着重要作用。然而，血清中抗B病毒X抗原循环抗体（抗-HBx）的意义尚不清楚。本文应用酶联免疫吸附试验（ELISA）检测了173例慢性B型肝炎（CH B）、106例肝硬化（LC）和61例肝癌患者血清中抗-HBx（IgG）的滴度。抗-HBx在肝硬化（40.6%）和肝癌（34.4%）中的阳性率明显高于慢性乙型肝炎（10.4%）（P <0.05）。340例抗-HBx阳性患者中，39例（97.5%）HBsAg/HBeAg/抗-HBc阳性，1例（2.5%）抗-HBs阳性（P <0.01），提示血清抗-HBx是HBV复制的标志物，而不是保护性抗体。因此，我们的研究结果表明，血清中的循环抗-HBx是由HBV介导的LC和HCC发展的标志之一。
Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma (HCC). However, the significance of circulating antibody to hepatitis B virus X antigen (anti-HBx) in sera remains unclear. In the present study, we examined the titers of anti-HBx (IgG) in the sera from 173 patients with chronic hepatitis B (CHB), 106 liver cirrhosis (LC), and 61 HCC by enzyme-linked immunosorbent assay (ELISA), respectively. Our data showed that the positive rates of anti-HBx were higher in sera of LC (40.6%) and HCC (34.4%) than those of CHB (10.4%), P < .05. In all 40 patients with anti-HBx+ out of 340 patients, 39 (97.5%) were HBsAg/HBeAg/anti-HBc+ and 1 (2.5%) was anti-HBs+ (P < .01), suggesting that anti-HBx in sera is a marker of HBV replication rather than a protective antibody. Thus, our findings reveal that circulating anti-HBx in sera is one of the markers of development of LC and HCC mediated by HBV.
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