One-year-old fear memories rapidly activate human fusiform gyrus.
One-year-old fear memories rapidly activate human fusiform gyrus.
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一岁的恐惧记忆迅速激活人类梭状回
DOI：
10.1093/scan/nsv122
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发表时间：
2016
影响因子：
4.2
通讯作者：
Pizzagalli
中科院分区：
文献类型：
--
作者：
Mueller;Pizzagalli
快速检测威胁对生存至关重要。与这种进化压力相一致，研究发现，在条件反射当天，威胁信号恐惧条件下的面孔会迅速（<80毫秒）激活包括梭状回在内的大脑视觉区域。远程恐惧条件刺激（CS）是否会引起类似的早期处理增强尚不清楚。本研究中，16名受试者在第1天接受了不同的面部恐惧条件反射和消退程序，并在条件反射后24小时（最近回忆测试）和9-17个月（远程回忆测试）进行了初始CS，同时记录了脑电图。采用数据驱动的脑电诱发事件相关电位分割方法，在近记忆和远记忆测试中识别出五种不同的微状态。为了探测颅内活动，使用低分辨率电磁断层扫描分析（LORETA）对每个微状态下的脑电图活动进行定位。在最近的（41-55和150-191毫秒）和远程（45-90毫秒）回忆测试中，恐惧条件反射的面孔增强了梭状回附近的快速激活，即使在没有意识到突发事件的参与者中也是如此。这些发现表明，条件反射面部的快速处理增强会持续一段时间。
Fast threat detection is crucial for survival. In line with such evolutionary pressure, threat-signaling fear-conditioned faces have been found to rapidly (<80 ms) activate visual brain regions including the fusiform gyrus on the conditioning day. Whether remotely fear conditioned stimuli (CS) evoke similar early processing enhancements is unknown. Here, 16 participants who underwent a differential face fear-conditioning and extinction procedure on day 1 were presented the initial CS 24 h after conditioning (Recent Recall Test) as well as 9-17 months later (Remote Recall Test) while EEG was recorded. Using a data-driven segmentation procedure of CS evoked event-related potentials, five distinct microstates were identified for both the recent and the remote memory test. To probe intracranial activity, EEG activity within each microstate was localized using low resolution electromagnetic tomography analysis (LORETA). In both the recent (41–55 and 150–191 ms) and remote (45–90 ms) recall tests, fear conditioned faces potentiated rapid activation in proximity of fusiform gyrus, even in participants unaware of the contingencies. These findings suggest that rapid processing enhancements of conditioned faces persist over time.
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影响因子：
3.7
作者：
Miskovic V;Keil A
通讯作者：
Keil A
DOI：
10.1073/pnas.1400335111
发表时间：
2014-02-25
影响因子：
11.1
作者：
LeDoux, Joseph E.
通讯作者：
LeDoux, Joseph E.
DOI：
10.1073/pnas.0509179102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Gelder, BC;Morris, JS;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
3.7
作者：
Stolarova, Margarita;Keil, Andreas;Moratti, Stephan
通讯作者：
Moratti, Stephan
影响因子：
2
作者：
Schiller, Daniela;Cain, Christopher K.;Phelps, Elizabeth A.
通讯作者：
Phelps, Elizabeth A.