Neuroglobin, a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders.
Neuroglobin, a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders.
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DOI：
10.3390/ijms13066995
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发表时间：
2012
影响因子：
5.6
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Yu Z;Liu N;Liu J;Yang K;Wang X
大脑神经元和组织通过激活内源性保护途径对亚致死损伤做出反应。最近，在大量旨在抑制特定缺血反应途径的中风保护策略临床试验失败后，内源性神经保护已成为开发中风和神经退行性疾病治疗方法的更有前景和希望的策略。神经球蛋白 (Ngb) 是一种氧结合球蛋白，在脑神经元中高度特异性表达。越来越多的证据清楚地表明，Ngb 是一种内源性神经保护分子，可对抗培养神经元和动物中的缺氧/缺血和氧化应激相关损伤，以及阿尔茨海默病等神经退行性疾病，因此任何能够上调内源性 Ngb 表达的药理学策略都可能导致针对这些脑部疾病的新疗法。在这篇综述中，我们总结了最近关于 Ngb 的生物学功能、基因表达调控和神经保护机制的研究。此外，还讨论了鉴定可上调内源性 Ngb 表达以针对中风和神经退行性疾病进行神经保护的化合物的策略。
Brain neurons and tissues respond to sublethal injury by activating endogenous protective pathways. Recently, following the failure of a large number of clinical trials for protective strategies against stroke that aim to inhibit a specific ischemia response pathway, endogenous neuroprotection has emerged as a more promising and hopeful strategy for development of therapeutics against stroke and neurodegenerative disorders. Neuroglobin (Ngb) is an oxygen-binding globin protein that is highly and specifically expressed in brain neurons. Accumulating evidence have clearly demonstrated that Ngb is an endogenous neuroprotective molecule against hypoxic/ischemic and oxidative stress-related insults in cultured neurons and animals, as well as neurodegenerative disorders such as Alzheimer’s disease, thus any pharmacological strategy that can up-regulate endogenous Ngb expression may lead to novel therapeutics against these brain disorders. In this review, we summarize recent studies about the biological function, regulation of gene expression, and neuroprotective mechanisms of Ngb. Furthermore, strategies for identification of chemical compounds that can up-regulate endogenous Ngb expression for neuroprotection against stroke and neurodegenerative disorders are discussed.
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