Protective efficacy of holed and aging PBO-pyrethroid synergist-treated nets on malaria infection prevalence in north-western Tanzania
Protective efficacy of holed and aging PBO-pyrethroid synergist-treated nets on malaria infection prevalence in north-western Tanzania
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经 PBO-拟除虫菊酯增效剂处理的有孔且老化的蚊帐对坦桑尼亚西北部疟疾感染流行率的保护作用
DOI：
10.1101/2022.04.13.22273828
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Lukole E
中科院分区：
文献类型：
--
作者：
Lukole E
自 2004 年以来，已向撒哈拉以南非洲地区分发了 20 亿个拟除虫菊酯长效杀虫蚊帐 (LLIN)，用于预防疟疾。目前的疟疾控制策略依赖于 LLIN 的假设有效寿命为 3 年。 PBO 增效剂 LLIN 是新推荐的一类网，但有关其寿命和社区中长期保护功效的信息有限。为了评估其运行生存率，我们对坦桑尼亚西部 396 个家庭的 390 个 PBO LLIN (Olyset Plus) 和 367 个标准拟除虫菊酯 LLIN (Olyset net) 进行了为期 36 个月的跟踪调查。为了评估 LLIN 状况与疟疾感染之间的关联，在分发后 4、9、16、21、28 和 33 个月的疟疾患病率横断面调查中对来自至少 480 个随机选择的家庭的蚊帐进行了评估。收集有关蚊帐的存在和状况的信息以及家庭的人口统计信息，以评估影响蚊帐耐用性的因素。 3年后，家庭中仍保留着所分发的蚊帐的不到17%。两种蚊帐的织物状况均与疟疾感染无关。当蚊帐使用 1 至 2 年之间时，不同蚊帐类型之间的差异最大，此时 PBO 蚊帐似乎与使用不到一年的蚊帐具有相似的保护作用，而无论织物状况如何，标准蚊帐随着老化，其保护作用要低得多。净类型之间的估计中位功能生存时间没有统计学差异，PBO LLIN 为 1.6 年（95% CI 1.38–1.87），标准 LLIN 为 1.9 年（95% CI 1.67–2.06）。 3 年后，两种蚊帐中的氯菊酯（拟除虫菊酯）含量损失了 55%，PBO LLIN 中的 PBO 含量损失了 97%。这些结果突出表明，两种网络类型的功能生存期均低于建议的 3 年。然而，即使网老化，PBO 网仍然比标准网更具保护性，无论其状况如何。
Two billion pyrethroid long-lasting insecticidal nets (LLINs) have been distributed since 2004 for malaria prevention in Sub-Saharan Africa. Current malaria control strategies rely on an assumed effective 3-year lifespan for LLINs. PBO synergist LLINs are a newly recommended class of net but there is limited information on their life span and long-term protective efficacy in communities. To assess their operational survival, a cohort of 390 PBO LLINs (Olyset Plus) and 367 standard pyrethroid LLIN (Olyset net) from 396 households were followed for 36 months in Western Tanzania. To assess the association between the condition of the LLIN and malaria infection, nets from at least 480 randomly selected households were assessed during malaria prevalence cross-sectional surveys at 4, 9, 16, 21, 28, and 33 months post-distribution. Information on the presence and condition of nets, and demographic information from the household, were collected to evaluate factors influencing net durability. After 3 years less than 17% of nets distributed still remained in the households. The fabric condition was not associated with malaria infection in either type of net. The difference between the net types was highest when nets were between 1–2 years old, when PBO nets appeared to be similarly protective as nets less than a year old, whereas standard nets were considerably less protective as they aged, regardless of fabric condition. There was no statistical difference in the estimated median functional survival time between net types with 1.6 years (95% CI 1.38–1.87) for PBO LLIN and 1.9 years (95% CI 1.67–2.06) for standard LLINs. After 3 years, there was a loss of 55% of permethrin (pyrethroid) content for both nets, and 97% of PBO content was lost in PBO LLIN. These results highlight that functional survival is less than the recommended 3 years for both net types. However, even as the nets age, the PBO nets remained more protective than standard nets, regardless of their condition.
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影响因子：
2.9
作者：
Mosha JF;Kulkarni MA;Messenger LA;Rowland M;Matowo N;Pitt C;Lukole E;Taljaard M;Thickstun C;Manjurano A;Mosha FW;Kleinschmidt I;Protopopoff N
通讯作者：
Protopopoff N
影响因子：
3.7
作者：
Agossa FR;Gnanguenon V;Anagonou R;Azondekon R;Aïzoun N;Sovi A;Oké-Agbo F;Sèzonlin M;Akogbéto MC
通讯作者：
Akogbéto MC
乌干达西部的基于聚酯的长期杀虫蚊网超过三年的使用寿命的证据。
影响因子：
3
作者：
Kilian A;Byamukama W;Pigeon O;Gimnig J;Atieli F;Koekemoer L;Protopopoff N
通讯作者：
Protopopoff N
从功效到效果：非洲经过杀虫剂处理的蚊帐。
影响因子：
11.1
作者：
C. Lengeler;Robert W. Snow
通讯作者：
Robert W. Snow
乌干达 LLIN 评估项目 (LLINEUP) – 乌干达经或不含胡椒基丁醚 (PBO) 处理的长效杀虫蚊帐的耐久性
DOI：
10.1101/2022.02.17.480046
发表时间：
2022
期刊：
bioRxiv
影响因子：
--
作者：
F. Mechan;Agaba Katureebe;Violet Tuhaise;Martin Mugote;Ambrose Oruni;Ismail Onyige;Kawesa Bumali;Jonathan Thornton;Kilama Maxwell;Mary Kyohere;M. Kamya;Peter Mutungi;Simon P. Kigozi;Adoke Yeka;J. Opigo;Catherine Maiteki;S. Gonahasa;J. Hemingway;G. Dorsey;L. Reimer;S. Staedke;M. Donnelly;A. Lynd
通讯作者：
A. Lynd