Topological organization of the "small-world" visual attention network in children with attention deficit/hyperactivity disorder (ADHD).
Topological organization of the "small-world" visual attention network in children with attention deficit/hyperactivity disorder (ADHD).
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DOI：
10.3389/fnhum.2014.00162
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发表时间：
2014
影响因子：
2.9
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Xia S;Foxe JJ;Sroubek AE;Branch C;Li X
背景：注意缺陷/多动障碍（ADHD）是最常见的儿童精神障碍。持续注意力中断是这种障碍中最显著的行为障碍之一。我们绘制了在视觉持续任务中负责持续注意力的神经网络的系统级拓扑属性，前提是网络特征的异常与ADHD的临床测量之间存在强烈的关联。方法：应用图论技术（GTT）和二元网络统计（NBS）对22例多动症合并型和22例年龄匹配的神经典型儿童的fMRI数据进行分析，评价其脑功能网络的拓扑结构和节点配对特征。然后对网络属性与临床措施之间的关系进行相关测试。结果：ADHD患者额、枕区视觉注意网络的局部效率和节点效率显著降低。对程度和中心性的测量表明，多动症患者的前扣带皮层功能亢进，眶额、枕中、颞上、中央上和边缘上脑回功能低下。在ADHD组中，NBS显示了包括右顶叶和颞叶以及左枕叶在内的内部网络的成对连接显著减少。结论：这些数据表明，视觉注意网络的非典型拓扑特征有助于典型的ADHD症状，并且可能是该综合征特征的注意力不集中和多动/冲动的基础。
Background: Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed childhood psychiatric disorder. Disrupted sustained attention is one of the most significant behavioral impairments in this disorder. We mapped systems-level topological properties of the neural network responsible for sustained attention during a visual sustained task, on the premise that strong associations between anomalies in network features and clinical measures of ADHD would emerge. Methods: Graph theoretic techniques (GTT) and bivariate network-based statistics (NBS) were applied to fMRI data from 22 children with ADHD combined-type and 22 age-matched neurotypicals, to evaluate the topological and nodal-pairing features in the functional brain networks. Correlation testing for relationships between network properties and clinical measures were then performed. Results: The visual attention network showed significantly reduced local-efficiency and nodal-efficiency in frontal and occipital regions in ADHD. Measures of degree and between-centrality pointed to hyper-functioning in anterior cingulate cortex and hypo-functioning in orbito-frontal, middle-occipital, superior-temporal, supra-central, and supra-marginal gyri in ADHD. NBS demonstrated significantly reduced pair-wise connectivity in an inner-network, encompassing right parietal and temporal lobes and left occipital lobe, in the ADHD group. Conclusions: These data suggest that atypical topological features of the visual attention network contribute to classic ADHD symptomatology, and may underlie the inattentiveness and hyperactivity/impulsivity that are characteristics of this syndrome.
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DOI：
10.1523/jneurosci.1776-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bressler SL;Tang W;Sylvester CM;Shulman GL;Corbetta M
通讯作者：
Corbetta M
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
10.6
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
4.1
作者：
Haldane, Morgan;Cunningham, Giles;Frangou, Sophia
通讯作者：
Frangou, Sophia