Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study.
Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study.
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针灸对原发性痛经患者的直接镇痛作用：fMRI研究。
DOI：
10.3389/fnins.2021.647667
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发表时间：
2021
影响因子：
4.3
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Wang Y;Xu J;Zhang Q;Zhang Q;Yang Y;Wei W;Guo X;Liang F;Yu S;Yang J
原发性痛经（PDM）是一种常见的妇科疾病，以下腹部疼痛为特征。针灸被认为是治疗PDM的一种很好的替代疗法。然而，针灸镇痛作用的主要机制在很大程度上是未知的。在本研究中，采用计算机生成的排列块随机化方法，将符合条件的患者随机分为真针灸组和假针灸组。研究队列共34例：真针组19例，假针组15例。收集患者月经期间的临床特征，并在患者月经前3天进行影像学扫描。我们分析了任务和静息功能磁共振成像（fMRI）数据，以探讨针刺干预对PDM疼痛强度的直接影响的潜在中枢机制。任务功能磁共振成像（fMRI）研究发现，在真实的针灸过程中，吻侧前扣带皮层（rACC）和右侧辅助运动区被激活。利用静息状态功能连通性（FC）方法，我们发现在真实针灸和假针灸的比较中，rACC和左中央前回的FC在治疗后与治疗前发生了变化。此外，基线时racc -左中央前回的FC与短期镇痛呈负相关，而针刺后racc -左中央前回的FC变化与短期镇痛呈正相关。这些发现支持了racc -左中央前回静息状态FC在针刺调节PDM疼痛强度中的重要性，这可能揭示了针刺治疗PDM的核心机制。
Primary dysmenorrhea (PDM) is a common gynecological disease characterized by lower abdominal pain. Acupuncture is considered a good alternative therapy for PDM. However, the central mechanism of the analgesic effect of acupuncture is largely unknown. In this study, eligible patients were randomized into the real and sham acupuncture groups using a computer-generated, permuted block randomization method. The study cohort comprised 34 patients: 19 in the real acupuncture group and 15 in the sham acupuncture group. The clinical characteristics of the patients during their menstrual period were collected, and imaging scans were performed during the first 3 days of the patients’ menstrual period. We analyzed task and resting functional magnetic resonance imaging (fMRI) data to investigate the potential central mechanism of the immediate effect of acupuncture intervention on the intensity of PDM pain. The task fMRI study found that the rostral anterior cingulate cortex (rACC) and right supplemental motor area were activated during real acupuncture. Using the resting-state functional connectivity (FC) method, we found a post- versus pre-treatment change in the FC of the rACC and left precentral gyrus in the comparison of real acupuncture versus sham acupuncture. In addition, the FC of the rACC–left precentral gyrus at baseline was negatively correlated with short-term analgesia, while the change in the FC of the rACC–left precentral gyrus was positively correlated with short-term analgesia after acupuncture treatment. These findings support the importance of rACC–left precentral gyrus resting-state FC in the modulation of the intensity of PDM pain through acupuncture, which may shed light on the central mechanism of acupuncture in the treatment of PDM.
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影响因子：
2.5
作者：
Farmer MA;Baliki MN;Apkarian AV
通讯作者：
Apkarian AV
基于全脑结构 MRI 的无痛期原发性痛经分类：一项机器学习研究。
影响因子：
7.4
作者：
Chen, Tao;Mu, Junya;Liu, Jixin
通讯作者：
Liu, Jixin
DOI：
10.1073/pnas.1312902110
发表时间：
2013-11-12
影响因子：
11.1
作者：
Kucyi, Aaron;Salomons, Tim V.;Davis, Karen D.
通讯作者：
Davis, Karen D.
影响因子：
8.8
作者：
Frölich MA;Deshpande H;Ness T;Deutsch G
通讯作者：
Deutsch G
影响因子：
6.7
作者：
Harada, Tasuku;Momoeda, Mikio;Hoshiai, Hiroshi
通讯作者：
Hoshiai, Hiroshi