COVID-19 Cardiovascular Connection: A Review of Cardiac Manifestations in COVID-19 Infection and Treatment Modalities.

COVID-19 Cardiovascular Connection: A Review of Cardiac Manifestations in COVID-19 Infection and Treatment Modalities.
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DOI:
10.1016/j.cpcardiol.2022.101186
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发表时间:
2023-08
影响因子:
4.2
通讯作者:
Gupta R
Gupta R
中科院分区:
医学3区
文献类型:
--
作者:
Maitz T;Parfianowicz D;Vojtek A;Rajeswaran Y;Vyas AV;Gupta R

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自 2020 年爆发以来,冠状病毒大流行已经严重削弱了医疗系统,并导致全球超过 260 万人死亡。 COVID-19 的临床表现包括从无症状携带者到严重肺炎,再到危及生命的急性呼吸窘迫综合征 (ARDS)。大流行的早期努力围绕着治疗 COVID-19 的肺部成分,然而,关于与该病毒相关的心脏并发症,已有大量数据。这被怀疑是由于明显的炎症反应以及直接的病毒损伤造成的。心律失常、急性心肌损伤、心肌炎、心肌病、血栓形成和心肌纤维化是一些观察到的心脏并发症。患有与 COVID-19 相关的心脏病的人的发病率和死亡率很高。此外,有记录显示出现典型心脏症状的患者随​​后被发现患有 COVID-19 感染。对于那些 COVID-19 检测呈阳性的人来说,临床上对该病毒的重要心脏成分的认识对于预防发病和死亡至关重要。不幸的是,针对 COVID-19 制定的治疗和预防措施已被证明也与心脏并发症有关。这是对 COVID-19 感染的心脏并发症和表现以及与治疗和疫苗接种相关的并发症和表现的全面回顾。
The coronavirus pandemic has crippled healthcare system since its outbreak in 2020, and has led to over 2.6 million deaths worldwide. Clinical manifestations of COVID-19 range from asymptomatic carrier to severe pneumonia, to life-threatening acute respiratory distress syndrome (ARDS). The early efforts of the pandemic surrounded treating the pulmonary component of COVID-19, however, there has been robust data surrounding the cardiac complications associated with the virus. This is suspected to be from a marked inflammatory response as well as direct viral injury. Arrhythmias, acute myocardial injury, myocarditis, cardiomyopathy, thrombosis, and myocardial fibrosis are some of the observed cardiac complications. There have been high morbidity and mortality rates in those affected by cardiac conditions associated with COVID-19. Additionally, there have been documented cases of patients presenting with typical cardiac symptoms who are subsequently discovered to have COVID-19 infection. In those who test positive for COVID-19, clinical awareness of the significant cardiac components of the virus is pertinent to prevent morbidity and mortality. Unfortunately, treatment and preventative measures developed for COVID-19 have been shown to be also be associated with cardiac complications. This is a comprehensive review of the cardiac complications and manifestations of COVID-19 infection in addition to those associated with both treatment and vaccination.
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