Accumulation of phase-shift nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation in vivo.
Accumulation of phase-shift nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation in vivo.
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DOI：
10.1260/2040-2295.4.1.109
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发表时间：
2013
影响因子：
--
通讯作者：
Porter TM
中科院分区：
文献类型：
--
作者：
Kopechek JA;Park E;Mei CS;McDannold NJ;Porter TM
磁共振引导的高强度聚焦超声（MRgHIFU）正在探索作为一种非侵入性技术来治疗实体肿瘤。然而，HIFU用于肿瘤消融应用的临床使用目前受到所需的长治疗时间的限制。相移纳米乳液（PSNE），由液体全氟化碳液滴，可以蒸发成微泡，正在开发，以加速HIFU介导的加热。本研究的目的是检查PSNE在体内兔肌内肿瘤中的积累。在静脉注射含钆PSNE之前和之后获得MR图像。注射后6小时，在兔肿瘤中观察到MR信号增强，表明PSNE在肿瘤中积累。此外，PSNE汽化检测在肿瘤与B型超声成像，和MR测温测量表明，PSNE加速HIFU介导的加热速率。这些结果表明，PSNE可以显着提高MRgHIFU的效率和临床可行性。
Magnetic resonance-guided high intensity focused ultrasound (MRgHIFU) is being explored as a non-invasive technology to treat solid tumors. However, the clinical use of HIFU for tumor ablation applications is currently limited by the long treatment times required. Phase-shift nanoemulsions (PSNE), consisting of liquid perfluorocarbon droplets that can be vaporized into microbubbles, are being developed to accelerate HIFU-mediated heating. The purpose of this study was to examine accumulation of PSNE in intramuscular rabbit tumors in vivo. MR images were acquired before and after intravenous injection of gadolinium-containing PSNE. MR signal enhancement was observed in rabbit tumors up to six hours after injection, indicating that PSNE accumulated in the tumors. In addition, PSNE vaporization was detected in the tumor with B-mode ultrasound imaging, and MR thermometry measurements indicated that PSNE accelerated the rate of HIFU-mediated heating. These results suggest that PSNE could dramatically improve the efficiency and clinical feasibility of MRgHIFU.
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影响因子：
3.3
作者：
Chung, Dong Jin;Cho, Se Hyun;Hahn, Seong-Tae
通讯作者：
Hahn, Seong-Tae
DOI：
10.1109/t-su.1970.29557
发表时间：
1970-01-01
期刊：
IEEE TRANSACTIONS ON SONICS AND ULTRASONICS
影响因子：
--
作者：
FRY, FS;HEIMBURGER, RF;EGGLETON, RC
通讯作者：
EGGLETON, RC
影响因子：
2.4
作者：
FRY, WJ;TUCKER, D;WULFF, VJ
通讯作者：
WULFF, VJ
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
2.4
作者：
Haworth, Kevin J.;Mast, T. Douglas;Holland, Christy K.
通讯作者：
Holland, Christy K.