Metabolomic applications to decipher gut microbial metabolic influence in health and disease.
Metabolomic applications to decipher gut microbial metabolic influence in health and disease.
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DOI：
10.3389/fphys.2012.00113
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发表时间：
2012
影响因子：
4
通讯作者：
Kochhar S
中科院分区：
文献类型：
--
作者：
Martin FP;Collino S;Rezzi S;Kochhar S
饮食偏好和营养成分已被证明影响人类和肠道微生物新陈代谢，最终对健康和疾病风险产生特定影响。越来越多的来自分子生物学和微生物学的结果表明，肠道微生物区系代谢界面对整个哺乳动物宿主的健康状况起着关键作用。因此，人们对营养学研究越来越感兴趣，以在生理和生化途径水平上表征肠道微生物-哺乳动物串扰的分子基础。应对这些挑战可以通过代谢组学等系统生物学方法来实现，以支持不同生物单元之间高度复杂的代谢交换，包括器官、全身生物液和微生物共生体。随着预测健康和疾病的特定生物标志物的发展，代谢组学越来越多地应用于临床应用，包括疾病病因、诊断分层以及潜在的治疗和营养解决方案的作用机制。令人惊讶的是，越来越多的代谢组学研究在临床前和临床研究中基于质子核磁共振(1H核磁共振)谱和质谱学提供了令人信服的证据，表明整个系统和特定器官的生化过程受到肠道微生物代谢的影响。该综述旨在描述代谢组学在临床领域的最新应用，主要目的是了解肠道微生物区系影响下的生化机制，洞察胃肠健康和疾病诊断以及改善体内平衡代谢调节。
Dietary preferences and nutrients composition have been shown to influence human and gut microbial metabolism, which ultimately has specific effects on health and diseases’ risk. Increasingly, results from molecular biology and microbiology demonstrate the key role of the gut microbiota metabolic interface to the overall mammalian host’s health status. There is therefore raising interest in nutrition research to characterize the molecular foundations of the gut microbial–mammalian cross talk at both physiological and biochemical pathway levels. Tackling these challenges can be achieved through systems biology approaches, such as metabolomics, to underpin the highly complex metabolic exchanges between diverse biological compartments, including organs, systemic biofluids, and microbial symbionts. By the development of specific biomarkers for prediction of health and disease, metabolomics is increasingly used in clinical applications as regard to disease etiology, diagnostic stratification, and potentially mechanism of action of therapeutical and nutraceutical solutions. Surprisingly, an increasing number of metabolomics investigations in pre-clinical and clinical studies based on proton nuclear magnetic resonance (1H NMR) spectroscopy and mass spectrometry provided compelling evidence that system wide and organ-specific biochemical processes are under the influence of gut microbial metabolism. This review aims at describing recent applications of metabolomics in clinical fields where main objective is to discern the biochemical mechanisms under the influence of the gut microbiota, with insight into gastrointestinal health and diseases diagnostics and improvement of homeostasis metabolic regulation.
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影响因子：
7.4
作者：
Bruce, Stephen J.;Tavazzi, Isabelle;Guy, Philippe A.
通讯作者：
Guy, Philippe A.
影响因子：
168.9
作者：
Cunningham, David;Atkin, Wendy;Starling, Naureen
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Starling, Naureen
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定植引起的宿主微生物代谢相互作用。
影响因子：
6.4
作者：
Claus SP;Ellero SL;Berger B;Krause L;Bruttin A;Molina J;Paris A;Want EJ;de Waziers I;Cloarec O;Richards SE;Wang Y;Dumas ME;Ross A;Rezzi S;Kochhar S;Van Bladeren P;Lindon JC;Holmes E;Nicholson JK
通讯作者：
Nicholson JK
影响因子：
2.5
作者：
Balasubramanian, Krithika;Kumar, Sandeep;Jagannathan, Naranamangalam R.
通讯作者：
Jagannathan, Naranamangalam R.