Blood index panel for gastric cancer detection.
Blood index panel for gastric cancer detection.
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DOI：
10.4240/wjgs.v14.i9.1026
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发表时间：
2022-09-27
影响因子：
2
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Guo GH;Xie YB;Zhang PJ;Jiang T
胃癌是一种常见的恶性肿瘤。早期发现和诊断是预防和治疗胃癌的关键。目的建立一种能提高胃癌与胃息肉鉴别诊断价值的血液指标。对139例胃癌患者和40例胃息肉患者的13项肿瘤相关检测指标、38项临床生化指标和10项细胞因子指标进行检测，建立模型。另外68例胃癌患者和22例胃息肉患者入组进行验证。在曲线下面积评估和单变量和多变量分析之后。胃癌组与胃息肉组的5项肿瘤相关检测指标、12项临床生化指标和1项细胞因子指标差异有统计学意义。碳水化合物抗原（CA）724、磷（P）和缺血修饰白蛋白（IMA）被纳入血液指标组，指标组的曲线下面积（AUC）为0.829（0.754，0.905）。验证后，AUC为0.811（0.700，0.923）。与常规指标CA724相比，血液指标组显示出显著增加的诊断价值。我们建立了一个包括CA 724、P和IMA的指数模型来区分胃癌和胃息肉组，这可能是一个潜在的临床诊断方法。
Gastric cancer is a common malignant tumor. Early detection and diagnosis are crucial for the prevention and treatment of gastric cancer. To develop a blood index panel that may improve the diagnostic value for discriminating gastric cancer and gastric polyps. Thirteen tumor-related detection indices, 38 clinical biochemical indices and 10 cytokine indices were examined in 139 gastric cancer patients and 40 gastric polyp patients to build the model. An additional 68 gastric cancer patients and 22 gastric polyp patients were enrolled for validation. After area under the curve evaluation and univariate and multivariate analyses. Five tumor-related detection indices, 12 clinical biochemical indices and 1 cytokine index showed significant differences between the gastric cancer and gastric polyp groups. Carbohydrate antigen (CA) 724, phosphorus (P) and ischemia-modified albumin (IMA) were included in the blood index panel, and the area under the curve (AUC) of the index panel was 0.829 (0.754, 0.905). After validation, the AUC was 0.811 (0.700, 0.923). Compared to the conventional index CA724, the blood index panel showed significantly increased diagnostic value. We developed an index model that included CA724, P and IMA to discriminate the gastric cancer and gastric polyp groups, which may be a potential diagnostic method for clinical practice.
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影响因子：
5.7
作者：
Wong HL;Rabkin CS;Shu XO;Pfeiffer RM;Cai Q;Ji BT;Yang G;Li HL;Rothman N;Gao YT;Zheng W;Chow WH
通讯作者：
Chow WH
DOI：
10.1093/jnci/djy088
发表时间：
2018-08-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Sauerbrei W;Taube SE;McShane LM;Cavenagh MM;Altman DG
通讯作者：
Altman DG
影响因子：
4.4
作者：
Venerito, Marino;Link, Alexander;Malfertheiner, Peter
通讯作者：
Malfertheiner, Peter
影响因子：
2.7
作者：
Zeyaullah M;AlShahrani AM;Ahmad I
通讯作者：
Ahmad I
影响因子：
3.8
作者：
Perez, GIP;Garza-Gonzalez, E;Olivares, AZ
通讯作者：
Olivares, AZ