Association of Helicobacter pylori Infection and Host Cytokine Gene Polymorphism with Gastric Cancer.
Association of Helicobacter pylori Infection and Host Cytokine Gene Polymorphism with Gastric Cancer.
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DOI：
10.1155/2021/8810620
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发表时间：
2021
影响因子：
2.7
通讯作者：
Ahmad I
中科院分区：
文献类型：
--
作者：
Zeyaullah M;AlShahrani AM;Ahmad I
2018年，各种类型的新病例的全球癌症负担随着数百万人的死亡而上升。根据GLOBOCAN 2018提取的数据，胃癌（GC）是地球仪中与癌症相关的第三大死亡原因。与幽门螺杆菌（Hp）相关的致癌性或致癌性感染被认为是胃癌发生的重要危险因素之一。它有助于增加细胞因子的产生，这些细胞因子在宿主细胞中生长之前引起炎症。幽门螺杆菌感染和宿主细胞内编码细胞因子的特定类型的多态性是导致宿主对GC易感性增加的重要因素。在这种观察的背景下，只有一小部分被感染的细胞会变成恶性的。这些疾病是Hp致病途径、宿主易感性、环境条件以及这些因素之间相互作用的差异的结果。很明显，携带具有高炎症水平和多态性的细胞因子基因的宿主倾向于表现出发展GC的风险增加，特别强调宿主细胞因子基因多态性。
The global cancer burden of new cases of various types rose with millions of death in 2018. Based on the data extracted by GLOBOCAN 2018, gastric cancer (GC) is the third leading cause of mortality related to cancer across the globe. Carcinogenic or oncogenic infections associated with Helicobacter pylori (Hp) are regarded as one of the essential risk factors for GC development. It contributes to the increased production of cytokines that cause inflammation prior to their growth in the host cells. Hp infections and specific types of polymorphisms within the host cells encoding cytokines are significant contributors to the hostʼs increased susceptibility in terms of the development of GC. Against the backdrop of such an observation is that only a small portion of the cells infected can become malignant. The diversities are a consequence of the differences in the pathogenic pathway of the Hp, susceptibility of the host, environmental conditions, and interplay between these factors. It is evident that hosts carrying cytokine genes with high inflammatory levels and polymorphism tend to exhibit an increased risk of development of GC, with special emphasis being placed on the host cytokines gene polymorphisms.
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DOI：
10.1073/pnas.90.12.5791
发表时间：
1993-06-15
影响因子：
11.1
作者：
COVACCI, A;CENSINI, S;RAPPUOLI, R
通讯作者：
RAPPUOLI, R
影响因子：
3.4
作者：
CRABTREE, JE;COVACCI, A;RAPPUOLI, R
通讯作者：
RAPPUOLI, R
DOI：
10.1073/pnas.93.25.14648
发表时间：
1996-12-10
影响因子：
11.1
作者：
Censini, S;Lange, C;Covacci, A
通讯作者：
Covacci, A
影响因子：
15.9
作者：
Blaser, MJ;Berg, DE
通讯作者：
Berg, DE
影响因子：
6.4
作者：
Bertuccio, Paola;Chatenoud, Liliane;La Vecchia, Carlo
通讯作者：
La Vecchia, Carlo